N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the κ opioid receptor
Compounds and pharmaceutically acceptable salts and solvates thereof are described. The compounds relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology and organic chemistry.
1. A compound having the formula:
wherein:
R 1 is selected from H or —OCH 2 CH 2 OH;
R 2 is selected from —NH—(CH 2 CH 2 O) a —Y or —NH—(CH 2 CH 2 O) a —Y;
Y is selected from —CH 3 , —CF 3 , or —OH;
a is selected from 0, 1, 2, 3 and 4;
or pharmaceutically acceptable salts and solvates thereof.
2. The compound of claim 1 having the formula selected from:
3. A pharmaceutical composition comprising the compound of claim 1 and at least one pharmaceutically acceptable excipient.
4. A composition of matter comprising the compound of claim 1 , wherein the compound is present in a dosage form.
5. A method of treating pain comprising administering the compound of claim 1 to a patient in need thereof.