Allergic rhinitis drug delivery implant

1. A method of treating tissue in a nasal cavity, comprising:

inserting a bioresorbable implant into a soft tissue of the nasal cavity, wherein the bioresorbable implant comprises:

a porous bioresorbable tube defined by a wall formed from one or more porous bioresorbable polymers, the porous bioresorbable tube including pores and an interior bore that extends from a first end to a second end, and

a pharmaceutical composition loaded in the wall of the porous bioresorbable tube and filling at least partially the interior bore of the porous bioresorbable tube; and

after inserting the bioresorbable implant into the soft tissue of the nasal cavity, releasing the pharmaceutical composition from the bioresorbable implant,

wherein the wall of the porous bioresorbable tube is configured to control a release rate of the pharmaceutical composition over time, the release rate is determined by:

(i) a release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube, wherein the release of the pharmaceutical composition loaded in the wall leaves channels in the wall, and

(ii) a release of the pharmaceutical composition from the interior bore:

(a) via a degradation of the one or more porous bioresorbable polymers,

(b) through the pores of the porous bioresorbable tube, and

(c) through the channels left by the release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube, wherein the release of the pharmaceutical composition from the interior bore occurs more quickly as the pharmaceutical composition loaded in the wall of the porous bioresorbable tube is released.

2. The method of claim 1 , wherein the one or more porous bioresorbable polymers comprise a plurality biodegradable polymers with different degradation rates such that releasing the pharmaceutical composition filling at least partially the interior bore comprises releasing the pharmaceutical composition filling at least partially the interior bore at a plurality of release rates, which are different from each other.

3. The method of claim 1 , wherein the bioresorbable implant comprises a plurality of segments, and

wherein each segment comprises a different biodegradable polymer such that releasing the pharmaceutical composition filling at least partially the interior bore comprises releasing the pharmaceutical composition filling at least partially the interior bore at a plurality of release rates that are different from each other.

4. The method of claim 1 , wherein the bioresorbable implant comprises a tip having a pointed shape, and

wherein inserting the bioresorbable implant into the soft tissue comprises piercing and penetrating the soft tissue using the tip of the bioresorbable implant.

5. The method of claim 4 , wherein inserting the bioresorbable implant comprises inserting the bioresorbable implant in the soft tissue using a delivery device attached to a distal end of an endoscope.

6. The method of claim 1 , wherein the pharmaceutical composition comprises at least one of:

one or more drugs, or

one or more therapeutic agents.

7. The method of claim 1 , wherein the release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube is faster than the release of the pharmaceutical composition from the interior bore.

8. A bioresorbable implant for use in a nasal region, comprising:

a porous bioresorbable tube defined by a wall formed from one or more porous bioresorbable polymers, the porous bioresorbable tube including pores and an interior bore that extends from a first end to a second end; and

a pharmaceutical composition loaded in the wall of the porous bioresorbable tube and filling at least partially the interior bore of the porous bioresorbable tube,

wherein a release rate of the pharmaceutical composition from the bioresorbable implant is determined by:

(i) a release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube, wherein the release of the pharmaceutical composition loaded in the wall leaves channels in the wall, and

(ii) a release of the pharmaceutical composition from the interior bore:

(a) via a degradation of the one or more porous bioresorbable polymers,

(b) through the pores of the porous bioresorbable tube, and

(c) through the channels left by the release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube, wherein the release of the pharmaceutical composition from the interior bore occurs more quickly as the pharmaceutical composition loaded in the wall of the porous bioresorbable tube is released.

9. The bioresorbable implant of claim 8 , wherein the bioresorbable implant comprises a plurality of segments.

10. The bioresorbable implant of claim 8 , wherein the bioresorbable implant comprises a tip having a pointed shape.

11. The bioresorbable implant of claim 8 , wherein an end of the bioresorbable implant is flared.

12. The bioresorbable implant of claim 8 , wherein the release of the pharmaceutical composition from the interior bore through the pores of the porous bioresorbable tube relates to at least one of a size or a quantity of the pores.

13. The bioresorbable implant of claim 8 , wherein the bioresorbable implant includes a first cap coupled to the first end and/or a second cap coupled to the second end.

14. The bioresorbable implant of claim 8 , wherein the release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube is faster than the release of the pharmaceutical composition from the interior bore.

15. A system, comprising:

a bioresorbable implant comprising:

a porous bioresorbable tube defined by a wall formed from one or more porous bioresorbable polymers, the porous bioresorbable tube including pores and an interior bore that extends from a first end to a second end; and

a pharmaceutical composition loaded in the wall of the porous bioresorbable tube and filling at least partially the interior bore of the porous bioresorbable tube,

wherein a release rate of the pharmaceutical composition from the porous bioresorbable tube is determined by:

(i) a release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube, wherein the release of the pharmaceutical composition loaded in the wall leaves channels in the wall, and

(ii) a release of the pharmaceutical composition from the interior bore:

(a) via a degradation of the one or more porous bioresorbable polymers,

(b) through the pores of the porous bioresorbable tube, and

(c) through the channels left by the release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube, wherein the release of the pharmaceutical composition from the interior bore occurs more quickly as the pharmaceutical composition loaded in the wall of the porous bioresorbable tube is released; and

a delivery device configured to insert the bioresorbable implant in a soft tissue of a nasal cavity.

16. The system of claim 15 , wherein the delivery device comprises a needle having a lumen, and

wherein the bioresorbable implant is deliverable into the soft tissue via the lumen of the needle.

17. The system of claim 15 , wherein the delivery device comprises an elongated shaft having a distal end releasably coupled to a proximal end of the bioresorbable implant.

18. The system of claim 17 , wherein the bioresorbable implant comprises a tip having a pointed shape configured to pierce and penetrate the soft tissue.

19. The system of claim 15 , wherein the release of the pharmaceutical composition loaded in the wall of the porous bioresorbable tube is faster than the release of the pharmaceutical composition from the interior bore.