Photo-crosslinker
Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.
1. A medical device comprising
a substrate comprising a substrate surface;
a coating layer disposed over the substrate surface, the coating layer comprising the linking agent comprising a compound having the structure;
wherein R 1 , R 2 , R 4 and R 5 are independently hydrogen; and R 3 is C1-C6 alkyl.
2. The medical device of claim 1 , the linking agent having the structure:
3. The medical device of claim 1 , comprising a vascular device.
4. The medical device of claim 1 , comprising a catheter.
5. The medical device of claim 1 , the substrate comprising at least one selected from the group consisting of a hydrogel polymer, a silicone, a polypropylene, a polystyrene, a poly(vinyl chloride), a polycarbonate, a poly(methyl methacrylate), and a parylene.
6. The medical device of claim 1 , the substrate comprising at least one selected from the group consisting of a polyolefin, a polystyrene, a poly(methyl)methacrylate, a polyacrylonitrile, a poly(vinylacetate), a poly(vinyl alcohol), a polyoxymethylene, a polyamide, a polyimide, a polyurethane, a phenolic, an amino-epoxy resin, and a polyester.
7. The medical device of claim 1 , the coating layer comprising a three-dimensional scaffolding structure.
8. The medical device of claim 1 , wherein R 3 is either a C5 alkyl or a C6 alkyl.