Fluid exchange catheter system

1. A method of administering at least one drug to a patient using a fluid exchange catheter system, wherein the fluid exchange catheter system comprises a first lumen having a proximal end, a distal end, and a lumen wall extending between the proximal end and the distal end; a second lumen having a proximal end, a distal end, and a lumen wall extending between the proximal end and the distal end; an exchange surface at the distal end of the first lumen comprising a plurality of pores enabling fluid exchange between the catheter and an environment surrounding the catheter; an aspiration mechanism operably connected to the proximal end of the first lumen; and an infusion mechanism operably connected to the proximal end of the second lumen, the method comprising:

(a) activating the infusion mechanism to infuse a solution comprising the at least one drug through the second lumen and to the patient for an infusion time period and at an infusion pressure and infusion flow rate while the aspiration mechanism is disabled;

(b) disabling the infusion mechanism to stop infusion;

(c) activating the aspiration mechanism to aspirate fluid from the patient through the first lumen for an aspiration time period and at an aspiration pressure and aspiration flow rate while the infusion mechanism is disabled;

(d) disabling the aspiration mechanism to stop aspiration; and

(e) repeating steps (a) through (d).

2. The method of claim 1 , further comprises periodically dispersing a fluid jet through the second lumen to remove substances that are blocking one or more of the pores of the exchange surface.

3. The method of claim 1 , further comprising monitoring at least one of the infusion pressure and the aspiration pressure.

4. The method of claim 1 , wherein the solution further comprises nutrients.

5. The method of claim 1 , wherein the exchange surface is selected from the group consisting of a filter, a membrane, a grid, and a mesh cage.

6. The method of claim 1 , wherein at least one of the infusion mechanism and the aspiration mechanism is a peristaltic pump.

7. The method of claim 1 , wherein each of the infusion mechanism and the aspiration mechanism is a peristaltic pump.

8. The method of claim 1 , wherein at least one of the infusion mechanism and the aspiration mechanism is a fluid container.

9. The method of claim 1 , wherein the first lumen is an outer lumen creating an interior lumen space and the second lumen is an inner lumen, wherein the distal end of the inner lumen is disposed within the interior lumen space of the outer lumen.

10. The method of claim 1 , wherein the distal end of the first lumen forms a catheter tip, and wherein a pattern of positive pressure in the second lumen and a synchronized pattern of negative pressure in the first lumen create fluid currents at the catheter tip for keeping the catheter tip unobstructed.

11. The method of claim 1 , wherein the distal end of the second lumen comprises at least one opening and the opening in the distal end of the second lumen is disposed at a proximal position relative to at least one opening in the distal end of the first lumen.

12. A method of unblocking a fluid exchange catheter, wherein the fluid exchange catheter comprises a first lumen having a proximal end, a distal end, and a lumen wall extending between the proximal end and the distal end; a second lumen having a proximal end, a distal end, and a lumen wall extending between the proximal end and the distal end; and an exchange surface at the distal end of the first lumen comprising a plurality of pores enabling fluid exchange between the catheter and an environment surrounding the catheter; the method comprising:

infusing a fluid through the second lumen and into the body for an infusion time period and at an infusion pressure and infusion flow rate while the aspiration mechanism is disabled;

aspirating fluid from the body through the first lumen for an aspiration time period and at an aspiration pressure and aspiration flow rate while the infusion is stopped; and

periodically dispersing a fluid jet through the second lumen to remove substances that are blocking one or more of the pores of the exchange surface.

13. The method of claim 12 , further comprising monitoring at least one of the infusion pressure and the aspiration pressure.

14. The method of claim 12 , wherein the fluid is a solution comprising one or more drugs.

15. The method of claim 12 , wherein the exchange surface is selected from the group consisting of a filter, a membrane, a grid, and a mesh cage.

16. The method of claim 12 , wherein infusing the fluid through the second lumen and into the body is performed by a peristaltic pump operably connected to the proximal end of the second lumen.

17. The method of claim 12 , wherein dispersing the fluid jet through the second lumen is performed by a peristaltic pump operably connected to the proximal end of the second lumen.

18. The method of claim 12 , wherein the first lumen is an outer lumen creating an interior lumen space and the second lumen is an inner lumen, wherein the distal end of the inner lumen is disposed within the interior lumen space of the outer lumen.

19. The method of claim 12 , wherein the distal end of the first lumen forms a catheter tip, and wherein a pattern of positive pressure in the second lumen and a synchronized pattern of negative pressure in the first lumen create fluid currents at the catheter tip for keeping the catheter tip unobstructed.

20. The method of claim 12 , wherein the distal end of the second lumen comprises at least one opening and the opening in the distal end of the second lumen is disposed at a proximal position relative to at least one opening in the distal end of the first lumen.