Mobile phone for treating a patient with dementia
Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
1. A system comprising:
a mobile device;
a stimulator comprising a signal generator for generating an electrical current, the stimulator being coupled to the mobile device, the stimulator including one or more electrodes adapted to contact an outer skin surface of a patient diagnosed with a neurodegenerative disease;
a control software within the mobile device, wherein the control software disables a function of the mobile device when the stimulator is enabled, wherein the function is other than stimulation control; and
wherein the stimulator transmits the electric current from the one or more electrodes transcutaneously through the outer skin surface, wherein the electric current modulates a vagus nerve at a target region within the patient and thereby modifies the neurodegenerative disease.
2. The system of claim 1 , wherein the electric current increases an inhibitory neurotransmitter in a brain of the patient such that an activity of a microglial cell is modified.
3. The system of claim 2 , wherein the electric current transitions the microglial cell from a M1 phenotype state to an M2 phenotype state.
4. The system of claim 1 , wherein the neurodegenerative disease includes at least one of dementia or Alzheimer's disease.
5. The system of claim 1 , wherein the neurodegenerative disease includes post-traumatic concussion.
6. The system of claim 1 , wherein the neurodegenerative disease includes ischemic stroke.
7. The system of claim 1 , wherein the mobile device is a mobile phone and the stimulator is housed within the mobile phone.
8. The system of claim 1 , wherein the mobile device is a mobile phone and the stimulator attaches to a surface of the mobile phone.
9. The system of claim 1 , wherein the mobile device is a mobile Wi-Fi device that receives and transmits data over the Internet.
10. The system of claim 1 , wherein the signal generator is situated within the mobile device.
11. The system of claim 1 , wherein the signal generator is located exterior to the mobile device and is wirelessly coupled to a software program.
12. The system of claim 11 , wherein the software program is a mobile application software program that is wirelessly downloaded onto the mobile device.
13. The system of claim 1 , further comprising:
an amplifier coupled to the one or more electrodes, wherein the amplifier amplifies the electrical signal to the one or more electrodes.
14. The system of claim 13 , wherein the amplifier is located within the mobile device.
15. The system of claim 1 , further comprising:
a base station that receives data from a remote source, wherein the base station is coupled to the stimulator and transmits the data to the stimulator, wherein the data includes a therapy regimen to treat the neurodegenerative disease.
16. The system of claim 1 , further comprising:
a control panel coupled to the control software, wherein the control panel modulates a property of the electric current.
17. The system of claim 16 , wherein the control panel modulates an amplitude of the electric current.
18. The system of claim 7 , wherein the electric current comprises bursts of about 2 pulses to about 20 pulses with each of the bursts having a frequency of about 1 burst per second to about 100 bursts per second and each of the pulses having a frequency of about 1 KHz to about 20 KHz.