Ophthalmic device packaging solutions comprising a poloxamine/erythritol mixture

1. A packaging system for the storage of an ophthalmic device comprising a sealed container that contains an unused, ophthalmic device in an aqueous packaging solution comprising:

(a) tris(hydroxymethyl)aminomethane or a salt thereof;

(b) one or more polysaccharides;

(c) one or more non-ionic surfactants comprising a poloxamine; and

(d) erythritol;

wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9; and

wherein the packaging system is heat sterilized subsequent to sealing of the packaging system.

2. The packaging system of claim 1 , wherein the tris(hydroxymethyl)aminomethane or a salt thereof is tris(hydroxymethyl)aminomethane hydrochloride.

3. The packaging system of claim 1 , wherein the aqueous packaging solution comprises about 0.001 to about 1 wt. %, based on the total weight of the aqueous packaging solution, of the tris(hydroxymethyl)aminomethane or salt thereof.

4. The packaging system of claim 1 , wherein the aqueous packaging solution further comprises one or more buffer agents.

5. The packaging system of claim 4 , wherein the one or more buffer agents are selected from the group consisting of a phosphate buffer agent, a borate buffer agent, a citrate buffer agent, a MOPS buffer agent and mixtures thereof.

6. The packaging system of claim 4 , wherein the aqueous packaging solution comprises about 0.001 to about 2 wt. %, based on the total weight of the aqueous packaging solution, of the one or more buffer agents.

7. The packaging system of claim 1 , wherein the aqueous packaging solution further comprises one or more of a borate compound, sodium phosphate, and sodium citrate.

8. The packaging system of claim 1 , wherein the one or more polysaccharides comprise an anionic polysaccharide or a non-ionic polysaccharide.

9. The packaging system of claim 1 , wherein the one or more polysaccharides comprise one or more of hyaluronic acid or a salt thereof, chondroitin sulfate, chitosan, aloe vera, carboxymethylcellulose, hemicellulose, hydroxypropyl methyl cellulose, methylcellulose, and ethylcellulose.

10. The packaging system of claim 1 , wherein the one or more polysaccharides comprise one or more of hyaluronic acid, sodium hyaluronate, and potassium hyaluronate.

11. The packaging system of claim 1 , wherein the aqueous packaging solution further comprises one or more additives selected from the group consisting of an antioxidant, a non-ionic surfactant other than a poloxamine, an osmolyte and mixtures thereof.

12. The packaging system of claim 1 , wherein the aqueous packaging solution further comprises one or more additives selected from the group consisting of L-Carnitine, and vitamin E TPGS (tocopherol polyethylene glycol succinate).

13. The packaging system of claim 1 , wherein the poloxamine comprises one or more of a poloxamine di(meth)acrylate, and a reverse poloxamine di(meth)acrylate, and the aqueous packaging solution further comprises one or more additives selected from the group consisting of a poloxamer di(meth)acrylate and a reverse poloxamer di(meth)acrylate.

14. The packaging system of claim 1 , wherein the aqueous packaging solution further comprises one or more additives selected from the group consisting of NaCl, KCl, taurine, glycine, diglycine, alanine; mannitol, sorbitol and propylene glycol.

15. The packaging system of claim 1 , wherein the ophthalmic device is a contact lens.

16. The packaging system of claim 1 , wherein the ophthalmic device is a hydrogel or silicone hydrogel contact lens.

17. The packaging system of claim 1 , wherein the aqueous packaging solution does not contain an effective disinfecting amount of a disinfecting agent.

18. The packaging system of claim 1 , wherein the aqueous packaging solution does not contain a germicide compound.

19. The packaging system of claim 1 , wherein the aqueous packaging solution further comprises one or more additives selected from the group consisting of taurine, carboxymethyl cellulose, hydroxypropylmethyl cellulose, a poly(dimethylacrylamide) polymer having a number average molecular weight of about 10400 to about 65400 and represented by the following structure:

wherein R is CN, OH or H, a polyvinyl pyrrolidone polymer having a number average molecular weight of about 5600 to about 31300 and represented by the following structure:

wherein R is CN, OH or H, a poly(acrylic acid)-grafted-poly(ethylene glycol) polymer represented by the following structure:

wherein m is 10 to 50, a is 10 to 50 and b is 10 to 50, a poly(acrylic acid)-co-poly(ethylene glycol) monoether acrylate copolymer represented by the structure:

wherein n is 10 to 50, a is 10 to 50 and b is 10 to 50, a poly(dimethylacrylamide)-co-poly(ethylene glycol methacrylate) copolymer represented by the following structure:

wherein m is 10 to 50, and n is 10 to 50, a poly(acrylic acid)-2-dimethyl ethylenediamine polymer having the structure:

wherein m is 10 to 50, a poly(acrylic acid)-ethylenediamine deprotected polymer having the structure:

wherein m is 10 to 50, and polyDMA-co-vinyl-4,4-Dimethyl-2-oxazoline-5-one polymer represented by the structure:

wherein m is 10 to 50 and n is 10 to 50.

20. The packaging system of claim 1 , wherein the aqueous packaging solution comprises:

(a) about 0.001 to about 1 wt. %, based on the total weight of the aqueous packaging solution, of the tris(hydroxymethyl)aminomethane or salt thereof;

(b) about 0.001 to about 10 wt. %, based on the total weight of the aqueous packaging solution, of the one or more polysaccharides;

(c) about 0.001 to about 10 wt. %, based on the total weight of the aqueous packaging solution, of the one or more non-ionic surfactants; and (d) 0.20 to 0.50%W/V of erythritol.