METHODS AND COMPOSITIONS FOR INHIBITING CD32B EXPRESSING CELLS
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
1 - 20 . (canceled)
21 . A method of treating cancer in a patient in need of such treatment, comprising:
administering to the patient an anti-human CD40 antibody comprising a light chain and a heavy chain, the heavy chain comprising a human IgG1 Fc domain comprising a S267E amino acid substitution, wherein the numbering is according to the EU index as in Kabat.
22 . The method of claim 21 , wherein the cancer is pancreatic cancer.
23 . The method of claim 21 , comprising administering the anti-human CD40 antibody in combination with one or more chemotherapeutic agents.
24 . The method of claim 23 , wherein the chemotherapeutic agent is gemcitabine.
25 . The method of claim 24 , wherein the one or more chemotherapeutic agents are gemcitabine in combination with paclitaxel.
26 . The method of claim 24 , comprising administering the anti-human CD40 antibody in combination with a second antibody.
27 . The method of claim 25 , comprising administering the anti-human CD40 antibody in combination with a second antibody.
28 . A method of causing B cell proliferation in a patient comprising:
contacting the B cell of the patient with an anti-human CD40 antibody comprising amino acid substitution S267E in the Fc region as compared to a parent human IgG1 Fc region, wherein the numbering is according to the EU index as in Kabat thereby causing B cell proliferation in the patient.