Granted Patent B2

US 11,229,595 · App. 16/425,283 · Granted Jan 25, 2022

Inventors: Jalil Bensaci (Issy-les-Moulineaux, FR); Thierry Oddos (Clamart, FR); Georgios N. Stamatas (Issy-les-Moulineaux, FR); Elea Greugny (Val de Reuil, FR)

Assignee: Johnson & Johnson Consumer Inc.

A61K9/0014G01N33/5014A61K9/06A61K2800/75

Abstract

Claims (11)

1. A method of evaluating an ability of a skin barrier system to protect infant skin from external irritants, comprising:

a) topically applying said barrier system to adult skin;

b) topically applying an external irritant to said barrier system treated adult skin;

c) observing the production of inflammatory molecules in said barrier system treated adult skin;

d) using a computational model of adult skin inflammation to visualize an effect of the external irritant by optimizing inflammation parameters so that the model of adult skin inflammation profiles match the experimental data;

e) transferring the optimized inflammation parameters to a computational model of infant skin; and

f) determining the impact of the irritant in the computational model of infant skin.

2. The method of claim 1 , wherein the irritant is selected from paraffin and petrolatum.

3. The method of claim 1 , wherein EPISIM is employed as the computational model of adult skin inflammation.

4. A barrier system selected by the method of claim 1 .

5. The method of claim 1 , wherein the computational model of adult skin inflammation is an agent-based model.

Assignments (8)