Methods for treating Friedreich's ataxia by an aromatic-cationic peptide to increase frataxin protein levels
The disclosure provides methods of preventing or treating Friedreich's ataxia in a mammalian subject, reducing risk factors, signs and/or symptoms associated with Friedreich's ataxia, and/or reducing the likelihood or severity of Friedreich's ataxia. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to e.g., reduce oxidative stress, increase mitochondrial metabolism, or a combination thereof.
1. A method for treating Friedreich's ataxia in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the peptide D-Arg-2′,6′-Dmt-Lys-Phe-NH2 or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the subject displays reduced levels of frataxin expression compared to a normal control subject.
3. The method of claim 1 , wherein the peptide is administered daily for 6 weeks or more.
4. The method of claim 1 , wherein the peptide is administered daily for 12 weeks or more.
5. The method of claim 1 , wherein the Friedreich's ataxia comprises one or more of muscle weakness, loss of coordination, vision impairment, hearing impairment, slurred speech, curvature of the spine, diabetes, and heart disorders.
6. The method of claim 1 , wherein the subject is human.
7. The method of claim 1 , wherein the peptide is administered orally, topically, systemically, intravenously, subcutaneously, intraperitoneally, or intramuscularly.
8. The method of claim 1 , further comprising separately, sequentially or simultaneously administering to the subject one or more therapeutic agents selected from the group consisting of ACE inhibitors, digoxin, enalapril, or lisinopril, diuretics, beta blockers, idebenone, deferiprone, and insulin.
9. The method of claim 1 , wherein the pharmaceutically acceptable salt comprises acetate or trifluoroacetate salt.