Precision dialysis therapy based on sorbent effluent analysis

1. A method comprising:

recharging zirconium phosphate in a sorbent module with a sorbent recharger by introducing one or more recharge solutions through the sorbent module,

wherein the one or more recharge solutions comprises at least water and a brine solution;

measuring at least one fluid parameter of an effluent from the sorbent module during recharging of the zirconium phosphate;

wherein the at least one fluid parameter of the effluent is measured in either an effluent line fluidly connected to the sorbent module or a reservoir fluidly connected to the effluent line; and

setting at least one dialysis parameter for a subsequent dialysis session for a patient based on the at least one fluid parameter of the effluent,

wherein the sorbent module was used by the patient in a previous dialysis session.

2. The method of claim 1 , wherein the at least one fluid parameter of the effluent is received from a at least one sensor in the effluent line or in the reservoir fluidly connected to the effluent line.

3. The method of claim 1 , wherein the at least one fluid parameter of the effluent comprises a total ammonia content in the effluent of the sorbent module; and wherein the total ammonia content in the effluent is received from an ammonia sensor.

4. The method of claim 3 , further comprising:

estimating a patient pre-dialysis blood urea nitrogen (BUN) level based on the total ammonia content of the effluent.

5. The method of claim 3 , wherein the setting at least one dialysis parameter for the subsequent dialysis session comprises setting at least one of: a dialysate flow rate, a blood flow rate, a dialyzer size, a zirconium phosphate sorbent module size, a sorbent cartridge size, a bicarbonate addition profile, dialysis session timing, dialysis session time, dialysis session frequency, or combinations thereof.

6. The method of claim 5 , wherein the setting at least one dialysis parameter for the subsequent dialysis session comprises reducing a dialysate flow rate, reducing a blood flow rate, reducing a dialyzer size, reducing a zirconium phosphate sorbent module size, reducing a sorbent cartridge size, increasing a bicarbonate addition profile, decreasing dialysis session frequency, or combinations thereof in response to a patient pre-dialysis BUN level below a patient pre-dialysis BUN level for a prior dialysis session.

7. The method of claim 2 , wherein the at least one sensor further comprises a pH sensor or a temperature sensor.

8. The method of claim 1 , wherein the method is performed by a processor of the sorbent recharger.

9. The method of claim 8 , wherein the processor is programmed to receive an ammonia content of the effluent at preset intervals or continuously.

10. The method of claim 1 , wherein the sorbent recharger recharges at least one sorbent material.

11. The method of claim 10 , wherein the recharging restores a functional capacity of the at least one sorbent material putting the at least one sorbent material back into a condition for reuse or use in a new dialysis session.

12. A system comprising:

an ammonium removal flow path comprising:

at least one ammonium removal solution source,

wherein the ammonium removal solution source is fluidly connectable to a zirconium phosphate module inlet;

a pump; and

an effluent line fluidly connectable to a zirconium phosphate module outlet,

wherein either the effluent line comprises at least one sensor, or further comprising a reservoir fluidly connected to the effluent line,

wherein the reservoir comprises at least one sensor;

a processor in communication with the at least one sensor,

wherein the at least one sensor measures a fluid parameter during recharging of the zirconium phosphate module after a previous dialysis session for a patient;

wherein the processor sets at least one dialysis parameter for a subsequent dialysis session of the patient based on the fluid parameter; and

a sorbent recharger,

wherein the ammonium removal flow path is a zirconium phosphate recharging flow path;

wherein the at least one ammonium removal solution source comprises at least one recharge solution source,

wherein the at least one recharge solution source comprises at least a water source and a brine source.

13. The system of claim 12 , wherein the at least one sensor is positioned in the effluent line.

14. The system of claim 12 , wherein the at least one sensor is positioned in the reservoir fluidly connected to the effluent line.

15. The system of claim 12 , wherein the at least one sensor is an ammonia sensor.

16. The system of claim 14 , wherein the at least one sensor further comprises a pH sensor or a temperature sensor.

17. The system of claim 12 , wherein the at least one dialysis parameter is selected from: a dialysate flow rate, a blood flow rate, a dialyzer size, a zirconium phosphate sorbent module size, a sorbent cartridge size, an amount of zirconium phosphate minimally required for therapy, a bicarbonate addition profile, dialysis session timing, dialysis session time, dialysis session frequency, or combinations thereof.

18. The system of claim 12 , wherein the at least one dialysis parameter is a bicarbonate addition profile.

19. The system of claim 12 , wherein the processor further estimates a patient pre-dialysis BUN level.

20. The system of claim 12 , wherein the processor is programmed to receive the fluid parameter from the at least one sensor at preset intervals or continuously.

21. The system of claim 12 , wherein the sorbent recharger recharges at least one sorbent material.

22. The system of claim 21 , wherein recharging restores a functional capacity of the at least one sorbent material putting the at least one sorbent material back into a condition for reuse or use in a new dialysis session.