Methods of treating hypertriglyceridemia
View Patent ↗In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
1. A method of reducing small LDL particle concentration in a subject having a fasting baseline triglyceride level of about 500 mg/dl to about 1500 mg/dl and a baseline small LDL particle concentration of about 800 nmol/L to about 1400 nmol/L, comprising, administering to the subject about 4 g per day of ethyl eicosapentaenoate thereby to produce a reduction in small LDL particle concentration by comparison with a baseline small LDL particle concentration prior to initiation of administration, wherein the small LDL particle has a diameter of 18.0-20.5 nm.
2. The method of claim 1 wherein the reduction in small LDL particle concentration is at least a 5% reduction.
3. The method of claim 1 wherein the reduction in small LDL particle concentration is at least a 9% reduction.
4. The method of claim 1 wherein the subject is administered about 3.8 g to about 4 g per day of ethyl eicosapentaenoate.
5. The method of claim 1 wherein the subject is administered ethyl eicosapentaenoate for a period of 12 weeks.