Heterocyclic compounds and uses thereof
Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.
1. A process of making compound 13:
said process comprising contacting compound 12:
with potassium tert-butoxide and iodomethane under conditions sufficient to form compound 13.
2. A process of making compound P-002:
said process comprising contacting compound 13:
with compound 13b:
in the presence of [1,1′-Bis(diphenyl-phosphino)ferrocene]dichloropalladium(II) under conditions sufficient to form compound P-002.
3. A process of making a compound P-001:
said process comprising contacting compound P-002:
with lithium hydroxide under conditions sufficient to form compound P-001.
4. A compound of formula:
5. A method for treating acute myeloid leukemia comprising administering to a subject in need thereof an effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof, and azacitidine.
6. A method for treating ovarian cancer comprising administering to a subject in need thereof an effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof, and carboplatin.