Methods and Systems for Low Power/Low Cost Hematocrit Measurement for Blood Glucose Meter
Systems and methods for hematocrit measurement are provided. The present disclosure provides systems and methods for a low power and low-cost utilization of a microprocessor to capture hematocrit measurements for a blood glucose meter. The systems and methods include an electronic meter for performing a diagnostic test on a sample applied to a test strip inserted. The electronic meter can include a low cost low power microcontroller for capturing the hematocrit measurements. The microcontroller includes trans-impedance amplifiers (TIAs) configured to read a current over the test strip to generate a response waveform, an analog-to-digital (ADC) converter to convert the response waveform into a digital value, a peak detector circuit configured to capture peak current magnitude of the response waveform, and a peak detector circuit configured to capture a peak current time
1 . A system for diagnostic testing comprising:
a test strip; and
an electronic meter for performing a diagnostic test on a sample applied to the test strip inserted therein, the electronic meter comprising:
a housing having a test port for receiving the test strip;
trans-impedance amplifiers (TIAs) configured to read a current over the test strip to generate a response waveform;
an analog-to-digital (ADC) converter to convert the response waveform into a digital value;
a peak detector circuit configured to capture peak current magnitude of the response waveform; and
a peak detector circuit configured to capture a peak current time.
2 . The system of claim 1 , wherein the reading the current over the test strip includes measuring a response current to an excitation voltage.
3 . The system of claim 1 , wherein the TIAs generate the response waveform from the current.
4 . The system of claim 3 , wherein the peak detector circuit captures the peak current time based on the captured peak current magnitude from the peak detector circuit and the response waveform from the TIAs.
5 . The system of claim 3 , wherein an excitation signal is applied to the blood sample such that the response to the excitation signal is analyzed to determine a glucose concentration in the blood sample.
6 . The system of claim 1 , wherein the TIAs convert current to a differential voltage waveform for analog-to-digital conversion by the ADC.
7 . The system of claim 9 , wherein a microprocessor is further programmed to detect when the sample is applied to the test strip.
8 . The system of claim 12 , wherein a microprocessor is further programmed to display a glucose concentration.
9 . A diagnostic testing device comprising:
a housing having a test port for receiving a test strip;
trans-impedance amplifiers (TIAs) configured to read a current over the test strip to generate a response waveform;
a peak detector circuit configured to capture peak current magnitude of the response waveform;
a peak detector circuit configured to capture a peak current time; and
an analog-to-digital (ADC) converter to convert the response waveform and the peak current magnitude into a digital value.
10 . The device of claim 9 , wherein the reading the current over the test strip includes measuring a response current to an excitation voltage.
11 . The device of claim 9 , wherein the TIAs generate the response waveform from the current.
12 . The device of claim 11 , wherein the peak detector circuit captures the peak current time based on the captured peak current magnitude from the peak detector circuit and the response waveform from the TIAs.
13 . The device of claim 11 , wherein an excitation signal is applied to the blood sample such that the response to the excitation signal is analyzed to determine a glucose concentration in the blood sample.
14 . The device of claim 13 , wherein the TIAs convert current to a differential voltage waveform for analog-to-digital conversion by the ADC.
15 . The device of claim 13 , wherein a microprocessor is further programmed to detect when the sample is applied to the test strip.
16 . The device of claim 15 , wherein a microprocessor is further programmed to display a glucose concentration.
17 . A method for a low cost and low power hematocrit testing, the method comprising:
applying a voltage to a sample on a test strip;
measuring, by trans-impedance amplifiers (TIAs), a current through the sample;
processing, by the TIAs, the current and outputting a voltage response waveform to an analog digital converter (ADC);
processing, by the peak detector, the voltage response waveform and outputting a peak current to the ADC; and
calculating and displaying hematocrit compensated glucose results based on the values received by the ADC.
18 . The method of claim 17 , further comprises:
outputting, by the TIAs, the voltage response waveform to a peak comparator; and
outputting, by the peak detector, the peak current to the peak comparator.
19 . The method of claim 18 , further comprises processing, by the peak comparator, the voltage response waveform and the peak current and outputting a peak time value.
20 . The method of claim 19 , calculating the compensated glucose results comprises:
calculating an HTC value based on the peak current and peak time value; and
adjusting a glucose measurement to the hematocrit compensated glucose results.