System and method for evaluating elution efficiency and radiopurity of tc-99m generators
A system for analyzing radiochemical purity of an eluate produced from a generator is provided. The system has an elution detector made of a shielding metal. The elution detector houses a flow path template for flow of an eluate solution and an elutable isotope contained in the generator, and a monitoring device for simultaneously monitoring the generator and the eluate exiting the generator. The generator is a Technetium-99m (Tc-99m) generator, and the elutable isotope may be contained in a packed bed of a column in the Tc-99m generator. A method for analyzing radiochemical purity of eluate produced from a Technetium-99m (Tc-99m) generator or column is also provided.
1. A system for analyzing radiochemical purity of an eluate produced from a generator, the system comprising:
an elution detector comprised of a shielding metal, wherein the elution detector houses a flow path template for flow of an eluate solution and an elutable isotope contained in the generator, and
a monitoring device for simultaneously monitoring the generator and the eluate exiting the generator.
2. The system according to claim 1 , wherein the generator is a Technetium-99m (Tc-99m) generator.
3. The system according to claim 2 , wherein the elutable isotope is contained in a packed bed of a column in the Tc-99m generator.
4. The system according to claim 3 , wherein the monitoring device monitors the packed bed of the column.
5. The system according to claim 1 , wherein the elutable isotope is contained in a slurry containing Tc-99m, another radioactive species, or both.
6. The system according to claim 1 , wherein the flow path template comprises a component selected from the group consisting of an eluate, filter, reservoir, a refillable vessel containing a virgin eluting solution, a pump, an embedded flow detector, a gamma detector, and a combination thereof.
7. The system according to claim 1 , wherein the elution detector has shielding walls.
8. The system according to claim 7 , wherein the shielding walls are comprised of the shielding metal.
9. The system according to claim 1 , wherein the shielding metal is selected from the group consisting of tungsten, lead, steel, and a combination thereof.
10. The system according to claim 1 , wherein the elution detector is communicatively connected to an output device.
11. The system according to claim 1 , wherein the flow path template is comprised of a metal selected from the group consisting of tungsten, lead, steel, and a combination thereof.
12. The system according to claim 1 , wherein the flow path template has a detector position.
13. The system according to claim 1 , wherein the elutable isotope is Mo-99.
14. A system for analyzing radiochemical purity of an eluate produced from a generator, the system comprising:
an elution detector comprised of a shielding metal, wherein the elution detector houses a flow path template for flow of an eluate solution and an elutable isotope contained in the generator, and
a monitoring device for simultaneously monitoring the generator and the eluate exiting the generator, and
wherein the flow path template comprises a component selected from the group consisting of an eluate, filter, reservoir, a refillable vessel containing a virgin eluting solution, a pump, an embedded flow detector, a gamma detector, and a combination thereof, and
wherein the embedded flow detector is placed to monitor a packed bed, an eluate before or after entering a filter media, and a combination thereof.
15. A method for analyzing radiochemical purity of eluate produced from a generator, the method comprising:
providing an elution detector comprised of a shielding metal, wherein the elution detector houses a flow path template and an elutable isotope contained in the generator,
eluting the generator containing the elutable isotope, and
simultaneously monitoring the generator and eluate exiting the generator.
16. The method according to claim 15 , wherein the generator is a Technetium-99m (Tc-99m) generator.
17. The method according to claim 16 , wherein the elutable isotope is contained in a packed bed of a column in the Tc-99m generator.
18. The method according to claim 15 , wherein the flow path template comprises a component selected from the group consisting of an eluate, filter, reservoir, a refillable vessel containing a virgin eluting solution, a pump, an embedded flow detector, a gamma detector, and a combination thereof.
19. The method according to claim 18 , wherein the gamma detector is used for measurement of the eluate in real time.
20. The method according to claim 18 , further comprising placing the gamma detector on a first eluting column to measure removal or exchange of Tc-99m.
21. The method according to claim 15 , wherein eluting occurs with a volume of eluting solution.
22. The method according to claim 21 , wherein the volume of eluting solution is saline, deionized water, another aqueous liquid, a non-aqueous liquid, or a combination thereof.
23. The method according to claim 21 , wherein the volume of eluting solution is incrementally passed through the packed bed of the column in the Tc-99m generator.
24. The method according to claim 23 , further comprising measuring the incremental volume for Tc and Mo content by gamma spectroscopy.
25. The method according to claim 15 , further comprising passing the eluate through a filter column one or more times.
26. The method according to claim 15 , further comprising counting by gamma spectroscopy in real time.
27. The method according to claim 15 , further comprising measuring for contaminates.
28. The method according to claim 15 , further comprising collecting a final full volume of the eluate to be counted.
29. The method according to claim 15 , wherein the elutable isotope is Mo-99.