System and method for dynamically calibrating and measuring analyte concentration in diabetes management monitors
An optical analyte sensor and diabetes management system is provided. The sensor preferably includes a hydrogel matrix for receiving a sample containing an analyte at unknown concentration, a light emitter for emitting light at a stimulation frequency, a light receiver for receiving a fluorescence signal at a first isosbestic frequency, and at a second frequency, for measuring an intensity of the fluorescence signal and the first and second frequencies. A processor determines a concentration of the analyte based on the respective intensities.
1. A diabetes management system, wherein the diabetes manage system comprises an optical analyte sensor, wherein the optical analyte sensor comprises:
a matrix for receiving a sample containing an analyte at an unknown concentration, and a marker configured to change between a first emission state and a second emission state in a presence of the analyte;
a light emitter for emitting light at a stimulation frequency upon the sample;
a light receiver configured to receive a fluorescence signal from the sample at each of the first emission state and the second emission state;
a processor; and
at least one computer-readable storage medium having encoded thereon instructions that, when executed by the processor, causes the processor to measure an intensity of the fluorescence signal at each of a first isosbestic frequency corresponding to the first emission state and a second variable frequency corresponding to the second emission state as a function of detection passband configurations, and to compare the intensity of and determine fractional concentrations of the first emission state and the second emission state of the fluorescence signal at each of the first isosbestic frequency and second variable frequency to determine a concentration of the analyte;
wherein the optical analyte sensor further comprises a transceiver for transmitting a signal indicative of the concentration of the analyte.
2. The diabetes management system of claim 1 , wherein the processor further determines an insulin requirement and wherein the signal transmitted comprises an insulin requirement based on the determined insulin requirement.
3. The diabetes management system of claim 1 , wherein the optical analyte sensor is an in-vitro sensor.
4. The diabetes management system of claim 1 , wherein the optical analyte sensor is an in-vivo sensor.
5. The diabetes management system of claim 1 , wherein the optical analyte sensor is a continuous sensor.
6. The diabetes management system of claim 1 , wherein the analyte is glucose.
7. The diabetes management system of claim 1 , wherein the analyte is hemoglobin HbAlc.
8. The diabetes management system of claim 1 , wherein the analyte is glycated albumin.