Three-dimensional microfluidics devices for the delivery of actives
A dermal delivery device includes a film having first and second outwardly facing major surfaces; at least one liquid reservoir contained within the film; at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir; and at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel.
1. A dermal delivery device comprising:
(a) a film having first and second outwardly facing major surfaces;
(b) a plurality of liquid reservoirs contained within the film;
(c) each liquid reservoir being in fluid communication with at least one microfluidic channel having a major transverse dimension between about 100 nm and 0.5 mm disposed within the film;
(d) at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with at least two microfluidic channels, wherein the at least two microfluidic channels intersect at a predetermined point located between the plurality of liquid reservoirs and the at least one outlet port and within the film.
2. The dermal delivery device of claim 1 further comprising a sensor.
3. The dermal delivery device of claim 2 wherein the sensor detects an amount of a liquid delivered over time.
4. The dermal delivery device of claim 1 wherein the plurality of liquid reservoirs contained within the film comprises at least a first liquid reservoir containing a first benefit agent and a second liquid reservoir containing a second benefit agent, different that the first benefit agent.
5. A transdermal delivery device comprising:
(a) a film having first and second outwardly facing major surfaces;
(b) at least one first liquid reservoir disposed within the film and containing a first benefit agent and at least one first microfluidic channel having a major transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one first liquid reservoir;
(c) at least one second liquid reservoir disposed within the film and containing a second benefit agent and at least one second microfluidic channel having a major transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one second liquid reservoir;
(d) an array of outlet ports comprising at least one first set of outlet ports being operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one first microfluidic channel and at least one second set of outlet ports being operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one second microfluidic channel, wherein at least one outlet port of the first set of outlet ports is disposed among the second set of outlet ports;
(e) at least one microneedle in fluid communication with the at least one outlet port.
6. The transdermal delivery device of claim 5 further comprising a sensor.
7. The transdermal delivery device of claim 6 wherein the sensor detects an amount of a liquid delivered over time.
8. A transdermal delivery device for long duration delivery of at least two benefit agents comprising:
(a) a film having first and second outwardly facing major surfaces;
(b) a first benefit agent subsystem comprising:
(i) at least one first active formulation liquid reservoir containing a first benefit agent disposed within the film;
(ii) at least one first benefit agent microfluidic channel having a major transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one first benefit agent liquid reservoir;
(iii) at least one set of first benefit agent outlet ports operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one first benefit agent microfluidic channel; and
(iv) at least one first benefit agent microneedle in fluid communication with the at least one first benefit agent outlet port; and
(c) a second benefit agent subsystem comprising:
(i) at least one second benefit agent liquid reservoir containing a second benefit agent disposed within the film;
(ii) at least one second benefit agent microfluidic channel having a major transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one second benefit agent liquid reservoir;
(iii) at least one set of second benefit agent outlet ports operatively connected to the second outwardly facing major surface of the film in fluid communication with the at least one second benefit agent microfluidic channel, wherein at least one outlet port of the first set of outlet ports is disposed among the second set of outlet ports; and
(iv) at least one second benefit agent microneedle in fluid communication with the at least one second benefit agent outlet port.
9. The transdermal delivery device of claim 8 further comprising a sensor.
10. The transdermal delivery device of claim 9 wherein the sensor detects an amount of a liquid delivered over time.