IP Library › Patent Application 16462198
Patent Application
App. No. 16/462,198

4-((6-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3(5-MERCAPTO-1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION

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Quick Facts
Patent No.
US None
App. No.
16/462,198
Abstract

Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydiOxy-3-(5-mercapto-1H-1,2,4-triazol-1-yl)piOpyl)pyridin-3-yl)oxy)benzonitrile.

Claims (8)

1 . A method of making a compound of Formula I

comprising the step of contacting a compound of Formula II

with elemental sulfur to form a mixture.

2 . The method of claim 1 , further comprising passing a gas through the mixture during the contacting.

3 . The method of claim 2 , wherein the gas is selected from air and nitrogen.

4 . The method of claim 1 further comprising a solvent selected from at least one of dimethylsulfoxide, N,N-dimethylformamide, N,N-dimethylacetamide, sulfolane, and N-methyl-2-pyrrolidone.

5 . The method of claim 1 wherein the contacting is carried out between about 50° C. and about 200° C.

6 . The method of claim 1 wherein the contacting is carried out between about 120° C. and about 180° C.