IP Library › Patent Application 16462202
Patent Application
App. No. 16/462,202

4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(5-MERCAPTO-1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
16/462,202
Abstract

Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.

Claims (12)

1 . A method of making a compound of Formula I comprising:

contacting a compound of Formula II

with a trialkyl orthoformate.

2 . The method of claim 1 , wherein the trialkyl orthoformate is selected from the group including triethyl orthoformate, trimethyl orthoformate, tripropyl orthoformate, and triisopropyl orthoformate.

3 . The method of claim 1 , wherein the contacting is carried out between about 50° C. and about 150° C.

4 . The method of claim 1 further comprising a solvent selected from the group including tetrahydrofuran, toluene, cyclopentyl methyl ether, acetonitrile, and mixtures thereof.

5 . The method of claim 1 further comprising the step of contacting a compound of Formula III:

with an acid to prepare the compound of Formula II.

6 . The method of claim 5 wherein the acid is selected from the group including HCl, HBr, TFA, and H 2 SO 4 .

7 . The method of claim 5 wherein the contacting is carried out between about 25° C. and about 75° C.

8 . The method of claim 5 further comprising a solvent selected from the group including methanol, ethanol, isopropanol, tetrahydrofuran, dioxane, and mixtures thereof.

9 . A compound consisting of: