IP Library › Patent Application 16462204
Patent Application
App. No. 16/462,204

4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(5-MERCAPTO-1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION

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Quick Facts
Patent No.
US None
App. No.
16/462,204
Abstract

Provided herein are methods for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1, 1-difluoro-2-hydroxy-3-(5-mer-capto-1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.

Claims (11)

1 . A method of making a compound of Formula I comprising:

contacting a compound of Formula II

with a base and an acid.

2 . The method of claim 1 , wherein the base is selected from the group including metal carbonates, metal alkoxides, and metal hydroxides.

3 . The method of claim 1 , wherein the base is selected from sodium hydroxide or potassium hydroxide.

4 . The method of claim 1 , wherein the acid is selected from the group including HCl, HBr, H 2 SO 4 , H 3 PO 4 and HNO 3 .

5 . The method of claim 1 , further comprising the step of contacting a compound of Formula III:

wherein R is H or t-BuO(CO);

with formic acid to prepare the compound of Formula II.

6 . The method of claim 5 wherein the contacting is carried out at between about 10° C. and about 100° C.

7 . A compound consisting of: