IP Library Granted Patent US 12,320,581
Granted Patent B2
US 12,320,581 · App. 16/463,705 · Granted Jun 3, 2025

Systems and methods for remotely monitoring the cryogenic processing of samples

Inventors: Alexander Nancekievill (Cambridge, GB); Rupert Rutledge (Cambridge, GB)
Assignee: BIOSAFE SA
F25D29/001A01N1/145A01N1/148A01N1/162B01L7/02B01L7/50F25D29/008G06F9/451G06F16/2379H04L67/125B01L2200/18B01L2300/023B01L2300/0663F25D2600/06
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Quick Facts
Patent No.
US 12,320,581
App. No.
16/463,705
Granted
Jun 3, 2025
Kind
B2
Abstract

A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server ( 130 ) is provided, capable of transmitting freezing profile data to one or more freezers ( 101, . . . , 10 n ), transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.

Claims (20)

1. A system for remotely monitoring cryogenic processing of a plurality of samples, the system comprising:

at least a plurality of thawing machines each for thawing a sample of the plurality of samples;

a remote server located remote from the plurality of thawing machines, the remote server configured to transmit same predetermined sample thawing profile data to each of the plurality of thawing machines;

wherein each of the plurality of thawing machines comprises at least one sensor, the at least one sensor configured to detect thawing sensor data relating to the thawing of the sample in accordance with the predetermined sample thawing profile data; and

wherein the remote server is further configured to receive a plurality of thawing sensor data from the plurality of thawing machines, the system being further characterised in that each respective thawing machine of the plurality of thawing machines further comprise a respective control module, the respective control module being configured to detect at least one of thawing machine data, sample thawing data and user data, relating to the thawing of the sample in accordance with the same predetermined sample thawing profile data transmitted to each of the plurality of thawing machines, the respective control module being further configured to provide a respective local user of the respective thawing machine with means to provide a sample ID associated with the sample and select the predetermined sample thawing profile from a plurality of predetermined sample thawing profiles, wherein the predetermined sample thawing profile is associated with the sample ID; and in that the remote server is further configured to receive from the plurality of thawing machines the detected thawing machine data, sample thawing data, and/or user data, generate a thawing consistency report from the received data that is indicative of thawing performance of the plurality of samples across the plurality of thawing machines indicative of at least one anomaly in the received data, and present the thawing consistency report to a remote user with a graphical representation of a single thawing machine of the plurality of thawing machines, a single user of a plurality of local users of the plurality of thawing machines, or a single predetermined thawing profile of the plurality of predetermined sample thawing profiles associated with the at least one anomaly.

2. The system of claim 1 , wherein the remote server is further configured to transmit an update to the predetermined sample thawing profile data to each of the plurality of thawing machines.

3. The system of claim 1 , wherein the remote server is configured to receive the detected data continuously, periodically or at an end of a thawing cycle from each of the plurality of thawing machines.

4. The system of claim 1 , wherein the remote server is configured to generate actual thawing graphs from the detected data received from each of the plurality of thawing machines.

5. The system of claim 1 , wherein the remote server is configured to compare the predetermined sample thawing profile to the detected data received from any of the plurality of thawing machines.

6. The system of claim 5 , wherein when the predetermined sample thawing profile deviates from the detected data received from any of the plurality of thawing machines, the remote server is further configured to provide a suggestion as to a cause of the deviation.

7. The system of claim 4 , wherein the remote server is configured to compare the actual thawing graphs generated for the plurality of thawing machines.

8. The system of claim 7 , wherein when the actual thawing graphs generated for the plurality of thawing machines deviates from one another, the remote server is further configured to provide a suggestion as to a cause of the deviation.

9. The system of claim 1 , wherein the remote server is configured to compare the detected data received from the plurality of thawing machines.

10. The system of claim 9 , wherein when the detected data received from the plurality of thawing machines deviates from one another, the remote server is further configured to provide a suggestion as to a cause of the deviation.

11. The system of claim 1 , wherein the remote server is configured to compare the detected data received from a group of thawing machines selected from the plurality of thawing machines.

12. The system of claim 1 , wherein the thawing sensor data comprise one or more of: at least one temperature within a thawing compartment of each of the plurality of thawing machines during a thawing cycle; a temperature at a heating unit of each of the plurality of thawing machines during a thawing cycle; an external temperature at each of the plurality of thawing machines during a thawing cycle; and thawing machine door data.

13. The system of claim 1 , wherein the thawing machine data comprises one or more of: a thawing machine identifier; thawing machine energy consumption during a thawing cycle; thawing machine location; and thawing machine alarm data.

14. The system of claim 1 , wherein the sample thawing data comprises one or more of: a sample identifier; sample composition data; sample size data; sample container data; sample thawing profile data; sample thaw date; and sample thaw time.

15. The system of claim 1 , wherein each of the plurality of thawing machines comprises a user interface, the user interface configured to receive user inputs relating to the thawing of the sample in accordance with the predetermined sample thawing profile data; and wherein the remote server is further configured to receive the user inputs.

16. The system of claim 1 , wherein the same predetermined sample thawing profile data is concurrently transmitted to each of the plurality of thawing machines.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 13, 2024
From: ASYMPTOTE LIMITED
To: BIOSAFE SA
Reel/Frame 068268/0460 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2019
From: NANCEKIEVILL, ALEXANDER; RUTLEDGE, RUPERT
To: ASYMPTOTE LTD.
Reel/Frame 051261/0318 →
Priority Claims (1)
GB 1620017 · Nov 25, 2016 · national
Continuity (1)
Related Publication 20190383554A1 · Dec 19, 2019
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