Swine vaccine
The invention pertains to a vaccine comprising in combination non-replicating immunogens of Erysipelothrix rhusiopathiae , porcine parvo virus, Leptospira interrogans and live attenuated PRRS virus, and a pharmaceutically acceptable carrier, for use in a method for prophylactic treatment of a swine against an infection with Erysipelothrix rhusiopathiae , porcine parvo virus, Leptospira interrogans and PRRS virus, wherein the vaccine is administered in a single dose with regard to the treatment against an infection with PRRS virus.
1. A method for prophylactically treating a swine that is seronegative for PRRS virus against an infection with Erysipelothrix rhusiopathiae , porcine parvo virus, Leptospira interrogans , and PRRS virus comprising administering a vaccine comprising a pharmaceutically acceptable carrier and a non-replicating immunogen of an Erysipelothrix rhusiopathiae , a non-replicating immunogen of a porcine parvo virus, a non-replicating immunogen of a Leptospira interrogans , and a live attenuated PRRS virus;
wherein the vaccine is administered in a single dose with regard to the treatment against an infection with PRRS virus to said swine that is seronegative for PRRS virus.
2. The method of claim 1 , wherein the non-replicating immunogen of the Erysipelothrix rhusiopathiae , the non-replicating immunogen of the porcine parvo virus, and the non-replicating immunogen of the Leptospira interrogans are inactivated pathogens of the Erysipelothrix rhusiopathiae , the porcine parvo virus, and the Leptospira interrogans , respectively.
3. The method of claim 1 , wherein the Leptospira interrogans pathogen comprises bacteria of the serogroup Pomona.
4. The method of claim 3 , further comprising a bacterium selected from the serogroup consisting of a Tarassovi, an Australis , a Grippotyphosa, an Icterohaemorrhagiae, and a Canicola.
5. The method of claim 4 , wherein the bacterium of the Australis is from a serovar Bratislava.
6. The method of claim 1 , wherein the vaccine is administered parenterally.
7. The method of claim 1 , wherein the vaccine is administered intramuscularly.
8. A kit for a swine that is seronegative for PRRS virus comprising a combination vaccine and a set of instructions; wherein the combination vaccine comprises a first vaccine comprising a pharmaceutically acceptable carrier and a non-replicating immunogen of an Erysipelothrix rhusiopathiae , a non-replicating immunogen of a porcine parvo virus, and a non-replicating immunogen of a Leptospira interrogans and a second vaccine comprising a freeze-dried live attenuated PRRS virus; and wherein the set of instructions state that:
(i) the second vaccine is to be mixed with the first vaccine to form the combination vaccine; and
(ii) the combination vaccine is to be administered to said swine that is seronegative for PRRS virus in a single dose with regard to the treatment against an infection with PRRS virus.
9. The kit of claim 8 , wherein the non-replicating immunogen of the Erysipelothrix rhusiopathiae , the non-replicating immunogen of the porcine parvo virus, and the non-replicating immunogen of the Leptospira interrogans are inactivated pathogens of the Erysipelothrix rhusiopathiae , the porcine parvo virus, and the Leptospira interrogans , respectively.