Prodrugs of lanicemine and their method of use
View Patent ↗Pharmaceutical compositions of the invention include substituted Lanicemine prodrugs useful for the treatment of conditions associated with dysregulation of NMDA receptor activity such as depression and depressive disorders through the release of Lanicemine, Prodrugs of Lanicemine have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release Lanicemine in the plasma via either an enzymatic or general biophysical release process.
1. A compound having formula (I):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein:
R 1 is selected from the group consisting of C 1 -C 6 fluoroalkyl, OR 2 , (CR 6a R 6b ) m NHR 7 ,
R 2 is selected from the group consisting of CH 2 (CH 2 ) n NR 3a R 3b ,
R 3a and R 3b are independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, and CO 2 R 4 ;
R 3a and R 3b cannot both be C 1 -C 6 alkyl;
R 3a and R 3b are taken together with the atom to which they are bound to form an optionally substituted three to six membered saturated heterocyclic ring consisting of two to five carbon atoms and a member selected from the group consisting of O, NR 5 , S, and SO 2 ;
n is 1 or 2;
R 4 is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 1 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, optionally substituted phenyl, and optionally substituted benzyl;
R 5 is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;
R 6a and R 6b are at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 3 -C 7 branched alkyl, optionally substituted C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;
R 6a and R 6b are taken together with the atom to which they are bound to form an optionally substituted 6 membered ring;
m is 1, 2, or 3;
R 7 is selected from the group consisting of COCR 8a R 8b (NHR 9 ),
R 8a and R 8b are at each occurrence independently selected from the group consisting of hydrogen, CH 3 , CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , CH 2 OH, CH(OH)CH 3 , CH 2 Ph, CH 2 (4-OH-Ph), (CH 2 ) 4 NH, (CH 2 ) 3 NHC(NH 2 )NH, CH 2 (3-indole), CH 2 (5-imidazole), CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 CONH 2 , and CH 2 CH 2 CONH 2 ;
R 9 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;
Y is at each occurrence independently selected from the group consisting of H 2 or O;
R 10a and R 10b are at each occurrence independently selected from the group consisting of hydrogen, CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , CH 2 OH, CH 2 OCH 2 Ph, CH(OH)CH 3 , CH 2 Ph, CH 2 (4-OH-Ph), (CH 2 ) 4 N 2 , (CH 2 ) 3 NHC(NH 2 )NH, CH 2 (3-indole), CH 2 (5-imidazole), CH 2 (CCH), CH2(cyclohexyl), CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 CONH 2 , and CH 2 CH 2 CONH 2 ;
R 10a and R 10b are taken together with the atom to which they are bound to form an optionally substituted three to six membered saturated carbocyclic ring;
R 11 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 1 -C 6 haloalkyl, and C 2 -C 6 alkynyl;
R 11 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, COCR 13a R 13b NR 15a R 15b , COCR 13a R 13b OR 14 , S 2 CR 13a R 13b NR 15a R 15b COCR 13a R 13b NHSO 2 R 15a
and (CR 19a R 19b ) q NHR 20 , and when R 12 is hydrogen, R 11 cannot be hydrogen;
R 11 and R 12 are taken together with the atom to which they are bound to form an optionally substituted four to six membered saturated heterocyclic ring containing a nitrogen atom and optionally containing an additional heteroatom from the group consisting of N and O;
R 13a and R 13b are at each occurrence independently selected from the group consisting of hydrogen, CH 3 , CH 2 CH 3 CH 2 CH 2 CH 3 , CH 2 CCH, CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , CH 2 OH, CH 2 OCH 2 Ph, CH 2 CH 2 OCH 2 Ph, CH(OH)CH 3 , CH 2 Ph, CH 2 (cyclohexyl), CH 2 (4-OH-Ph), (CH 2 ) 4 NH 2 , (CH 2 ) 3 NHC(NH 2 )NH, CH 2 (3-indole), CH 2 (5-imidazole), CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 CONH 2 , and CH 2 CH 2 CONH 2 ;
R 13a and R 13b are taken together with the atom to which they are bound to form an optionally substituted three to six membered saturated carbocyclic ring;
R 13a and R 13b are taken, together with the atom to which they are bound to form an optionally substituted six membered saturated heterocyclic ring with one O atom within the ring;
R 13a and R 14 are taken together with the atoms to which they are bound to form an optionally substituted four to six membered ring containing one nitrogen atom;
R 13a and R 15b are taken together with the atoms to which they are bound to form an optionally substituted four to six membered ring containing one nitrogen atom;
Y 1 is at each occurrence independently selected from the group consisting of H 2 , O, and —H/—OCH 2 Ph;
R 14 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;
R 15a and R 15b are at each occurrence independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl C 1 -C 6 fluoroalkyl, COR 21 , CH 2 R 21 , SO 2 R 22 , an optionally substituted four to six membered saturated heterocyclic ring containing a heteroatom selected from the group consisting of
R 15a and R 15b are taken together with the atom to which they are bound to form an optionally substituted three to six membered saturated heterocyclic ring consisting of two to five carbon atoms and a member selected from the group consisting of O, NR 5 , S, and SO 2 ;
R 16 is at each occurrence independently selected from the group consisting of CH 2 , O, C═O, and NH;
R 17 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;
R 18 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;
R 17 and R 18 are taken together with the atoms to which they are bound to form an optionally substituted five or six membered ring containing two nitrogen atoms;
R 19a and R 18b are at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 3 -C 7 branched alkyl, optionally substituted C 3 -C 7 cycloalkyl, optionally substituted C 2 -C 6 alkenyl, and optionally substituted C 2 -C 6 alkynyl;
R 19a and R 19b are taken together with the atom to which they are bound to form an optionally substituted 3 to 6 membered carbocyclic ring;
R 20 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;
q is 1, or 2;
R 2′ is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 fluoroalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
R 22 is at each occurrence independently selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl;
R 23 is selected from the group consisting of H, CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH 2 CCH, CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , CH 2 OH, CH 2 OCH 2 Ph, CH 2 CH 2 OCH 2 Ph, CH(OH)CH 3 , CH 2 Ph, CH 2 (cyclohexyl), CH 2 (4-OH-Ph), (CH 2 ) 4 NH 2 , (CH 2 ) 3 NHC(NH 2 )NH, CH 2 (3-indole), CH 2 (5-imidazole), CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 CONH 2 , and CH 2 CH 2 CONH 2 ;
R 24 is at each occurrence independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, COR 25 , and SO 2 —C 1-6 alkyl;
R 25 is at each occurrence independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 7 branched alkyl, C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, C 3 -C 6 alkoxy, and C 1 -C 6 alkylamino,
wherein substituted refers to a moiety having one or more hydrogen atoms replaced with a substituent selected from the group consisting of halogen, —CN, —NO 2 , ═O, —OR 26 , —SR 26 , —N(R 26 ) 2 , —NR 26 C(O)R 26 , —SO 2 R 26 , —SO 2 OR 26 , —SO 2 N(R 26 ) 2 , —C(O)R 26 , —C(O)OR 26 , —C(O)N(R 26 ) 2 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 2-8 alkenyl, C 2-8 alkynyl, C 3-14 cycloalkyl, aryl, heterocycle, or heteroaryl, wherein each of the alkyl, haloalkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocycle, and heteroaryl groups is optionally substituted with 1 to 10 groups selected independently from the group consisting of halogen, —CN, —NO 2 , ═O, and R 26 , wherein R 26 , at each occurrence, independently is hydrogen, —OR 27 , —SR 27 , —C(O)R 27 , —C(O)OR 27 , —C(O)N(R 27 ) 2 , —SO 2 R 27 , —S(O) 2 OR 27 , —N(R 27 ) 2 , —NR 27 C(O)R 27 , C 1-6 alkyl, C 1-6 haloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-6 cycloalkyl aryl, heterocycle, or heteroaryl, or two R 26 units taken together with the atom(s) to which they are bound form an optionally substituted carbocycle or heterocycle wherein said carbocycle or heterocycle has 3 to 7 ring atoms, wherein R 27 , at each occurrence, independently is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-6 cycloalkyl, aryl, heterocycle, or heteroaryl, or two R 27 units taken together with the atom(s) to which they are bound form an optionally substituted carbocycle or heterocycle wherein said carbocycle or heterocycle has 3 to 7 ring atoms.
2. The compound of claim 1 having the formula (II):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 having the formula (II):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 having the formula (IV):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 having the formula (V):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 having the formula (VI):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 having the formula (VII):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 having the formula (VIII):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 having the formula (IX):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 having the formula (X):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 having the formula (XI):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
12. The compound of claim 1 having the formula (XII):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 having the formula (XIII):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
14. The compound of claim 1 having the formula (XIV):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 having the formula (XV):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
16. The compound of claim 1 having the formula (XVI):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
17. The compound of claim 1 having the formula (XVII):
or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof.
18. The compound according to claim 1 that is:
Methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester;
2-Methylamino-N-(1-phenyl-2-pyridin-2-yl-ethyl)-acetamide;
2-Methylamino-N-(1-phenyl-2-pyridin-2-yl-ethyl)-acetamide;
{[({Methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid tert-butyl ester;
2-Amino-N-({methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-acetamide;
tert-Butyl-({methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamic acid benzyl ester;
2-tert-Butylamino-N-methyl-N-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]acetamide;
2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pyrrolidine-2-carboxamide;
(R)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)propanamide;
3-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) propanamide;
1-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) cyclopropane-1-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)azetidine-2-carboxamide;
2-amino-2-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(S)-2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-3-hydroxy-N-(2-oxo-2-((2-(4-pyridyl2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pent-4-ynamide;
(S)-2-amino-N-(2-oxo-2-(2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pent-4-ynamide;
(R)—N-(2)-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pyrrolidine-2-carboxamide;
1-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)cyclobutane-1-carboxamide;
(S)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pentanamide;
(R)-2-amino-3-methyl-N-(2-oxo-2-((2-(2-pyridyl-1-(phenyl)ethyl)amino)ethyl)butanamide;
(S)-4-oxo-N-(2-oxo-2-(2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)pyrrolidine-2-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperidine-2-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)morpholine-3-carboxamide;
(R)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)morpholine-3-carboxamide;
(R)-2-amino-4-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pentanamide;
(R)-4-oxo-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperidine-2-carboxamide;
4-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)tetrahydro-2H-pyran-4-carboxamide;
(R)-2-amino-N1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pentanediamide;
(R)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-3-phenylpropanamide;
(R)-2-amino-3-cyclohexyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-3-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(S)-2-amino-3-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-3-(1H-indol-3-yl)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(2S,4R)-4-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pyrrolidine-2-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperazine-2-carboxamide;
(R)-2-amino-4-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)butanamide;
(S)-1-glycyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)azetidine-2-carboxamide;
(S)-1-(3-aminopropanoyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)azetidine-2-carboxamide
(S)-1-(1-(aminomethyl)cyclopropane-1-carbonyl)-N-(2-(2-pyridyl)-(phenyl)ethyl)azetidine-2-carboxamide;
(S)-1-(1-(aminomethyl)cyclopentane-1-carbonyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)azetidine-2-carboxamide;
(S)-1-glycyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
(S)-1-(3-aminopropanoyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
(S)-1-(3-aminopropanoyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
(R)-1-(methylglycyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
1-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclopropane-1-carboxamide;
1-(2-(methylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclopropane-1-carboxamide;
1-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(2-(methylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(3-amino-2,2-dimethylpropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(aminomethyl)-N-(1-((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)cyclobutyl) cyclopentane-1-carboxamide;
1-(2-(isopropylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(2-(isopropylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(aminomethyl)-N-(1-((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)cyclobutyl) cyclohexane-1-carboxamide;
(R)-1-(2-aminopropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethylcyclobutane-1-carboxamide;
(R)-1-(2-amino-3-methylbutanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
(S)-2-(2-aminoacetamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-(2-(methylamino)acetamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-((R)-2-aminopropanamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-((S)-2-aminopropanamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(R)-2-amino-3-methyl-N—((S)-1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)butanamide;
(S)-2-amino-2-methyl-N-(1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
(S)-1-amino-N-(1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopropane-1-carboxamide;
(S)-1-amino-N-(1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclobutane-1-carboxamide;
1-(3-amino-2,2-dimethylpropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
(R)-2-(2-aminopropanamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-(2-aminopropanamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-aminoacetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(R)-2-amino-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)-3-phenylpropanamide;
(S)-2-amino-3-(benzyloxy)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
1-amino-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopropane-1-carboxamide;
1-amino-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclobutane-1-carboxamide;
2-amino-2-methyl-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
3-amino-2,2-dimethyl-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
1-(aminomethyl)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopropane-1-carboxamide;
1-(aminomethyl)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopentane-1-carboxamide;
1-(aminomethyl)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclohexane-1-carboxamide;
2-methyl-2-(2-(methylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-(ethylamino)acetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-(isopropylamino)acetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-(tert-butylamino)acetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-amino-N—((S)-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethylamino)propan-2-yl)propanamide;
(R)-2-amino-N—((S)-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
3-Amino-N,2,2-trimethyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
1-(aminomethyl)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclopropane-1-carboxamide;
1-(aminomethyl)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclopentane-1-carboxamide;
1-(aminomethyl)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexane-1-carboxamide;
N-methyl-2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(ethylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(isopropylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(tert-butylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(dimethylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl) amino)ethyl)acetamide;
2-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
(S)-2-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
3-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl) propanamide;
2-amino-N-ethyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino) ethyl)acetamide;
2-amino-N-isopropyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(aminomethyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)benzamide;
tert-butyl (4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)carbamate;
4-amino-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)—N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl) pyrrolidine-2-carboxamide;
(S)-2-amino-4-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pentanamide;
4-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)-4-(2-aminopropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethylbutanamide;
(S)-2-amino-3-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)butanamide;
(S)-5-oxo-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pyrrolidine-2-carboxamide;
(2S,3S)-2-amino-3-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pentanamide;
(S)-4-amino-5-oxo-5-((4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethylamino)butyl)amino)pentanoic acid;
(S)-2-amino-4-(methylthio)-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)butanamide;
(S)-4-(2-amino-3-phenylpropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethylbutanamide;
(S)-3-amino-4-oxo-4-((4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethylamino) butyl)amino) butanoic acid;
(S)-4-amino-5-oxo-5-((4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)amino)pentanoic acid;
(S)-4-(2-amino-3-(1H-indol-3-yl)propanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)—N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(S)—N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(S)-2-amino-4-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pentanamide;
(S)-2-amino-3-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)butanamide;
2-amino-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) cyclohexyl)methyl)acetamide;
(S)-2-amino-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)propanamide;
2-(methylamino)-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) cyclohexyl)methyl)acetamide;
(R)-2-amino-3-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)butanamide;
(S)-5-oxo-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(S)-2-amino-N1-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)cyclohexyl)methyl)pentanediamide;
(S)-2-amino-4-(methylthio)-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)butanamide;
(S)-2-amino-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)-3-phenylpropanamide;
(S)-3-amino-4-oxo-4-(((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)amino)butanoic acid;
(S)-4-amino-5-oxo-5-(((I-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)amino)pentanoic acid;
(S)-2-amino-3-(1H-indol-3-yl)-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)propanamide;
(R)-2-amino-3-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)butanamide;
(R)—N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pyrrolidine-2-carboxamide;
(R)-5-oxo-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pyrrolidine-2-carboxamide;
(R)-2-amino-3-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) cyclohexyl)methyl)butanamide;
(S)—N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(R)-5-oxo-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl) methyl)pyrrolidine-2-carboxamide;
4-amino-3,3-dimethyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)-3-(benzyloxy)-2-morpholino-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-3-(benzyloxy)-2-(dimethylamino)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(ethylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(isopropylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
N-methyl-2-(methylsulfonamido)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(tert-butoxy)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
N,4,4-trimethyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) pentanamide;
tert-Butyl-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)amino)-2-oxoethyl)(1-(trifluoromethyl)cyclopropyl)carbamate;
N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-2-((1-(trifluoromethyl)cyclopropyl)amino)acetamide;
N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-2-((2,2,2-trifluoroethyl)amino)acetamide hydrochloride;
2-acetamido-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) acetamide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)propionamide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)butyramide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)isobutyramide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)benzamide;
2,2,2-trifluoro-N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) amino)-2-oxoethyl)acetamide;
N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetamide;
2-(2-oxopiperazin-1-yl)-N-(2-(2-pyridyl)-1-(phenyl)ethylacetamide;
(S)—N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperazine-2-carboxamide;
(R)—N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperazine-2-carboxamide;
Benzyl (2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy)ethyl)carbamate;
2-aminoethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
Benzyl ethyl(2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy) ethyl)carbamate;
2-(Ethylamino)ethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
Benzyl methyl(2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy) ethyl)carbamate;
2-(Methylamino)ethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
Benzyl isopropyl(2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy)ethyl)carbamate;
2-(Isopropylamino)ethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
4-amino-2,2-dimethyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)-2-amino-N1,N5-bis(2-(2-pyridyl)-1-(phenyl)ethyl)pentanediamide;
2-(dimethylamino)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)acetamide;
1,3-bis(2-(2-pyridyl)-1-(phenyl)ethyl)urea;
or a pharmaceutically acceptable salt thereof.
19. A composition comprising an effective amount of at least one compound according to claim 1 and at least one excipient.
20. The composition according to claim 19 , wherein the at least one compound is at least one member selected from the group consisting of:
Methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester;
2-Methylamino-N-(1-phenyl-2-pyridin-2-yl-ethyl)-acetamide;
2-Methylamino-N-(1-phenyl-2-pyridin-2-yl-ethyl)-acetamide;
{[({Methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid tert-butyl ester;
2-Amino-N-({methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-acetamide;
tert-Butyl-({methyl-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamic acid benzyl ester;
2-tert-Butylamino-N-methyl-N-[(1-phenyl-2-pyridin-2-yl-ethylcarbamoyl)-methyl]-acetamide;
2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pyrrolidine-2-carboxamide;
(R)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)propanamide;
3-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) propanamide;
1-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclopropane-1-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)azetidine-2-carboxamide;
2-amino-2-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(S)-2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-3-hydroxy-N-(2-oxo-2-((2-(4-pyridyl2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pent-4-ynamide;
(S)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pent-4-ynamide;
(R)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pyrrolidine-2-carboxamide;
1-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)cyclobutane-1-carboxamide;
(S)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pentanamide;
(R)-2-amino-3-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)butanamide;
(S)-4-oxo-N-(2-oxo-2-(2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)pyrrolidine-2-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperidine-2-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)morpholine-3-carboxamide;
(R)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)morpholine-3-carboxamide;
(R)-2-amino-4-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pentanamide;
(R)-4-oxo-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperidine-2-carboxamide;
4-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)tetrahydro-2H-pyran-4-carboxamide;
(R)-2-amino-N1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pentanediamide;
(R)-2-amino-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-3-phenylpropanamide;
(R)-2-amino-3-cyclohexyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-3-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(S)-2-amino-3-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-3-(1H-indol-3-yl)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(2S,4R)-4-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)pyrrolidine-2-carboxamide;
(S)—N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperazine-2-carboxamide;
(R)-2-amino-4-(benzyloxy)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)butanamide;
(S)-1-glycyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)azetidine-2-carboxamide;
(S)-1-(3-aminopropanoyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)azetidine-2-carboxamide
(S)-1-(1-(aminomethyl)cyclopropane-1-carbonyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)azetidine-2-carboxamide;
(S)-1-(1-(aminomethyl)cyclopentane-1-carbonyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)azetidine-2-carboxamide;
(S)-1-glycyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
(S)-1-(3-aminopropanoyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
(S)-1-(3-aminopropanoyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
(R)-1-(methylglycyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)piperidine-2-carboxamide;
1-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclopropane-1-carboxamide;
1-(2-(methylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclopropane-1-carboxamide;
1-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(2-(methylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(3-amino-2,2-dimethylpropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(aminomethyl)-N-(1-((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)cyclobutyl) cyclopentane-1-carboxamide;
1-(2-(isopropylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(2-(isopropylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
1-(aminomethyl)-N-(1-((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)cyclobutyl) cyclohexane-1-carboxamide;
(R)-1-(2-aminopropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethylcyclobutane-1-carboxamide;
(R)-1-(2-amino-3-methyl butanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
(S)-2-(2-aminoacetamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-(2-(methylamino)acetamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-((R)-2-aminopropanamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-((S)-2-aminopropanamido)-3-phenyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(R)-2-amino-3-methyl-N—((S)-1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)butanamide;
(S)-2-amino-2-methyl-N-(1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
(S)-1-amino-N-(1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopropane-1-carboxamide;
(S)-1-amino-N-(1-oxo-3-phenyl-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclobutane-1-carboxamide;
1-(3-amino-2,2-dimethylpropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)cyclobutane-1-carboxamide;
(R)-2-(2-aminopropanamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-(2-aminopropanamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-aminoacetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(R)-2-amino-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)-3-phenylpropanamide;
(S)-2-amino-3-(benzyloxy)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
1-amino-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopropane-1-carboxamide;
1-amino-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclobutane-1-carboxamide;
2-amino-2-methyl-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
3-amino-2,2-dimethyl-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
1-(aminomethyl)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopropane-1-carboxamide;
1-(aminomethyl)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclopentane-1-carboxamide;
1-(aminomethyl)-N-(2-methyl-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)cyclohexane-1-carboxamide;
2-methyl-2-(2-(methylamino)acetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-(ethylamino)acetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-(isopropylamino)acetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(2-(tert-butylamino)acetamido)-2-methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-2-amino-N—((S)-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethylamino)propan-2-yl)propanamide;
(R)-2-amino-N—((S)-1-oxo-1-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)propan-2-yl)propanamide;
3-Amino-N,2,2-trimethyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
1-(aminomethyl)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclopropane-1-carboxamide;
1-(aminomethyl)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclopentane-1-carboxamide;
1-(aminomethyl)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexane-1-carboxamide;
N-methyl-2-(methylamino)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(ethylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(isopropylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(tert-butylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(dimethylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl) amino)ethyl)acetamide;
2-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino) ethyl)acetamide;
(S)-2-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
(R)-2-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)propanamide;
3-amino-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl) propanamide;
2-amino-N-ethyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino) ethyl)acetamide;
2-amino-N-isopropyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(aminomethyl)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)benzamide;
tert-butyl (4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)carbamate;
4-amino-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)—N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl) pyrrolidine-2-carboxamide;
(S)-2-amino-4-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pentanamide;
4-(2-aminoacetamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)-4-(2-aminopropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethylbutanamide;
(S)-2-amino-3-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)butanamide;
(S)-5-oxo-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pyrrolidine-2-carboxamide;
(2S,3S)-2-amino-3-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pentanamide;
(S)-4-amino-5-oxo-5-((4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethylamino)butyl)amino)pentanoic acid;
(S)-2-amino-4-(methylthio)-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)butanamide;
(S)-4-(2-amino-3-phenylpropanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethylbutanamide;
(S)-3-amino-4-oxo-4-((4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethylamino) butyl)amino) butanoic acid;
(S)-4-amino-5-oxo-5-((4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)amino)pentanoic acid;
(S)-4-(2-amino-3-(1H-indol-3-yl)propanamido)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)—N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(S)—N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(S)-2-amino-4-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl) amino)ethyl)cyclohexyl)ethyl)pentanamide;
(S)-2-amino-3-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)butanamide;
2-amino-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) cyclohexyl)methyl)acetamide;
(S)-2-amino-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)propanamide;
2-(methylamino)-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) cyclohexyl)methyl)acetamide;
(R)-2-amino-3-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)butanamide;
(S)-5-oxo-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(S)-2-amino-N1-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)cyclohexyl)methyl)pentanediamide;
(S)-2-amino-4-(methylthio)-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)butanamide;
(S)-2-amino-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)-3-phenylpropanamide;
(S)-3-amino-4-oxo-4-(((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)amino)butanoic acid;
(S)-4-amino-5-oxo-5-(((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)amino)pentanoic acid;
(S)-2-amino-3-(1H-indol-3-yl)-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)propanamide;
(R)-2-amino-3-methyl-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)butanamide;
(R)—N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pyrrolidine-2-carboxamide;
(R)-5-oxo-N-(4-oxo-4-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)butyl)pyrrolidine-2-carboxamide;
(R)-2-amino-3-methyl-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) cyclohexyl)methyl)butanamide;
(S)—N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl)methyl)pyrrolidine-2-carboxamide;
(R)-5-oxo-N-((1-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)cyclohexyl) methyl)pyrrolidine-2-carboxamide;
4-amino-3,3-di methyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)-3-(benzyloxy)-2-morpholino-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
(S)-3-(benzyloxy)-2-(dimethylamino)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)propanamide;
2-(ethylamino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
2-(isopropyl amino)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
N-methyl-2-(methylsulfonamido)-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenylethyl)amino)ethyl)acetamide;
2-(tert-butoxy)-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)acetamide;
N,4,4-trimethyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) pentanamide;
tert-Butyl-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethylamino)ethyl)amino)-2-oxoethyl)(1-(trifluoromethyl)cyclopropyl)carbamate;
N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-2-((1-(trifluoromethyl)cyclopropyl)amino)acetamide;
N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-2-((2,2,2-trifluoroethyl)amino)acetamide hydrochloride;
2-acetamido-N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) acetamide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)propionamide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)butyramide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)isobutyramide;
N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)amino)-2-oxoethyl)benzamide;
2,2,2-trifluoro-N-(2-(methyl(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl) amino)-2-oxoethyl)acetamide;
N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetamide;
2-(2-oxopiperazin-11-yl)-N-(2-(2-pyridyl)-1-(phenyl)ethylacetamide;
(S)—N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperazine-2-carboxamide;
(R)—N-methyl-N-(2-oxo-2-((2-(2-pyridyl)-1-(phenyl)ethyl)amino)ethyl)piperazine-2-carboxamide;
Benzyl (2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy)ethyl)carbamate;
2-aminoethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
Benzyl ethyl(2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy) ethyl)carbamate;
2-(Ethylamino)ethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
Benzyl methyl(2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy) ethyl)carbamate;
2-(Methylamino)ethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
Benzyl isopropyl(2-(((2-(2-pyridyl)-1-(phenyl)ethyl)carbamoyl)oxy)ethyl)carbamate;
2-(Isopropylamino)ethyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (2-(2-pyridyl)-1-(phenyl)ethyl)carbamate;
4-amino-2,2-dimethyl-N-(2-(2-pyridyl)-1-(phenyl)ethyl)butanamide;
(S)-2-amino-N1,N5-bis(2-(2-pyridyl)-1-(phenyl)ethyl)pentanediamide;
2-(dimethylamino)-N-(2-(2-pyridyl)-1-(phenyl)ethyl)acetamide;
1,3-bis(2-(2-pyridyl)-1-(phenyl)ethyl)urea;
or a pharmaceutically acceptable salt thereof.
21. A method for treating depression and depressive disorders, said method comprising administering to a subject an effective amount of at least one compound according to claim 1 .
22. The method of claim 21 , wherein the at least one compound is administered in a composition further comprising at least one excipient.
23. A method for treating major depressive disorder, said method comprising administering to a subject an effective amount of at least one compound according to claim 1 .
24. The method of claim 23 , wherein the at least one compound is administered in a composition further comprising at least one excipient.
25. A method for treating or pain, said method comprising administering to a subject an effective amount of at least one compound according to claim 1 .
26. The method of claim 25 , wherein the at least one compound is administered in a composition further comprising at least one excipient.
27. A method for treating neuropathic pain, said method comprising administering to a subject an effective amount of at least one compound according to claim 1 .
28. The method of claim 27 , wherein the at least one compound is administered in a composition further comprising at least one excipient.
29. A method for treating diseases and conditions associated with dysregulation of NMDA receptor activity, said method comprising administering to a subject an effective amount of at least one compound according to claim 1 .
30. The method of claim 29 , wherein the at least one compound is administered in a composition further comprising at least one excipient.
31. The method of claim 29 wherein the diseases and conditions associated with dysregulation of NMDA receptor activity is selected from the group consisting of Rett Syndrome, suicidal ideation, bipolar disorder, bipolar depression, obsessive compulsive disorder, sarin gas poisoning, and status epilepticus.
32. The method of claim 30 wherein the diseases and conditions associated with dysregulation of NMDA receptor activity is selected from the group consisting of Rett Syndrome, suicidal ideation, bipolar disorder, bipolar depression, obsessive compulsive disorder, sarin gas poisoning, and status epilepticus.