Use of vimentin in the modulation of acute inflammation and thrombosis
Embodiments of the disclosure include methods and compositions for treating or preventing acute inflammation using soluble vimentin. In specific embodiments, a vimentin derivative comprising the rod domain is utilized for treating or preventing any disease in which a decrease in leukocyte adhesion is therapeutic. In specific embodiments, a fragment of vimentin that comprises part or all of the rod domain is employed.
1. A method of treating or preventing acute
inflammation in an individual, comprising the step of delivering to the individual a therapeutically effective amount of vimentin (SEQ ID NO: 1) or a functionally active fragment of vimentin or variant thereof,
wherein the fragment is no more than 400 amino acids in length and comprises the sequence FANYIDKVRFLEOONKILLAELEOLKGOGK.
2. The method of claim 1 , wherein the acute inflammation comprises acute lung injury, secondary lung injury, acute respiratory distress syndrome, ischemia/reperfusion injury, trauma, sepsis, pancreatitis, drug-induced organ injury, or a combination thereof.
3. The method of claim 1 , wherein the individual has acute lung injury or acute respiratory distress syndrome.
4. The method of claim 1 , wherein the individual is provided a second therapy for the medical condition.
5. The method of claim 1 , wherein the method further comprises diagnosis of the medical condition.
6. The method of claim 1 , wherein the fragment of vimentin is delivered to the individual intravenously, intradermally, transdermally, intrathecally, intraarterially, intraperitoneally, intranasally, intravaginally, intrarectally, topically, intramuscularly, subcutaneously, mucosally, orally, topically, locally, by inhalation, by injection, by infusion, via catheter, and/or via lavage.
7. The method of claim 1 , wherein the fragment of vimentin is delivered to the individual multiple times.
8. The method of claim 7 , wherein the fragment of vimentin is delivered to the individual once a day, more than once a day, more than once a week, more than once a month, or more than once a year.
9. The method of claim 1 , wherein the fragment of vimentin is provided to the individual by constant infusion.
10. The method of claim 1 , wherein the wherein the fragment is no more than 30, 40, or 50 amino acids in length.