Porous microparticles of biodegradable polymer, and polymer filler comprising same

1. Porous microparticle of biodegradable polymer, having

i) spherical shape,

ii) particle diameter of 10 to 50 μm,

iii) pore with a diameter of 0.1 to 10 μm, and

iv) porosity ratio of 10 to 20%; and

d 10 of greater than 20 μm, d 90 of less than 60 μm, and a span value of less than 0.8;

wherein the span value is calculated by the following equation:

span

=

D

90

-

D

10

D

50

wherein D 10 , D 50 and D 90 represent size values corresponding to 10%, 50%, and 90%, respectively, of the maximum value in accumulated distribution of particles, represented as the particle sizes corresponding to 1/10, 5/10, and 9/10, respectively, of the particle size distribution curve showing the relatively accumulated amounts of particles according to the size when it is measured, plotted and divided into 10 fractions;

wherein the biodegradable polymer is at least one selected from the group consisting of poly(lactic acid), poly(glycolic acid), poly(dioxanone), poly(caprolactone), poly(lactic acid-co-glycolic acid), poly(dioxanone-co-caprolactone), poly(lactic acid-co-caprolactone), derivatives thereof and copolymers thereof.

2. The porous microparticle of biodegradable polymer according to claim 1 , wherein the biodegradable polymer has a number average molecular weight (Mn) in a range of 10,000 to 1,000,000 g/mol.

3. Polymer filler comprising:

the porous microparticle of biodegradable polymer according to claim 1 ; and

one or more biocompatible carriers.

4. The polymer filler according to claim 3 , wherein the biocompatible carrier is selected from carboxymethyl cellulose, hyaluronic acid, dextran, collagen and combinations thereof.

5. The polymer filler according to claim 3 , wherein, based on 100% by weight of the polymer filler, the amount of the porous microparticle of biodegradable polymer is 10 to 50% by weight and the amount of the biocompatible carrier is 50 to 90% by weight.

6. The polymer filler according to claim 3 , which is prepared in an injection formulation.

7. The polymer filler according to claim 3 , which is used for wrinkle improvement, facial plastic procedure or body plastic procedure.