Methods and compositions comprising biodegradable cyanoacrylates
Disclosed herein are methods of making and using cyanoacrylate compositions comprising one or more cyanoacrylates, a high level of at least one stabilizing agent and at least one free-radical polymerization inhibitor. Methods disclosed comprise making such compositions and using such compositions, for example, for occluding conduits such as fallopian tubes.
1 . A biodegradable cyanoacrylate composition, consisting essentially of,
a) a cyanoacrylate component consisting of methoxyisopropyl cyanoacrylate and methoxypropyl cyanoacrylate, wherein the cyanoacrylate component is 99 wt % or greater of the total weight of the biodegradable cyanoacrylate composition;
b) a stabilizer component of sulfur dioxide in a range from 600 ppm to 1500 ppm; and
c) a polymerization inhibitor component of butylated hydroxy anisole (BHA) in a range from 4000 to 7000 ppm,
wherein the viscosity of the composition is from about 10 cP to about 30 cP;
with a cure or setting time between 10 seconds and 30 seconds; and
wherein the composition fails to pass a Neutral Red cytotoxicity test (as measured by ISO 10993-5:2009) and passes genotoxicity testing (as measured by ISO 10993-3:2003).
2 . The biodegradable cyanoacrylate composition of claim 1 , further comprising a plasticizing agent, biocompatible agent, thickening agent, medicament, crosslinking agent, dye or pigment, preservative, antimicrobial agent, or polymerization initiator or accelerator.
3 . The biodegradable cyanoacrylate composition of claim 1 , wherein the composition is sterile.
4 . A biodegradable cyanoacrylate composition, comprising,
a. a cyanoacrylate component consisting of methoxyisopropyl cyanoacrylate and methoxypropyl cyanoacrylate, wherein the cyanoacrylate component is 99 wt % or greater of the total weight of the biodegradable cyanoacrylate composition;
b. a stabilizer component of sulfur dioxide in a range from 600 ppm to 1500 ppm; and
c. a polymerization inhibitor component of butylated hydroxy anisole (BHA) in a range from 4000 to 7000 ppm.
5 . The biodegradable cyanoacrylate composition of claim 4 , further comprising a plasticizing agent, biocompatible agent, thickening agent, medicament, crosslinking agent, dye or pigment, preservative, antimicrobial agent, or polymerization initiator or accelerator.
6 . The biodegradable cyanoacrylate composition of claim 4 , wherein the composition is sterile.
7 . The biodegradable cyanoacrylate composition of claim 5 , wherein the composition is sterile.