IP Library Granted Patent US 11,953,493
Granted Patent B2
US 11,953,493 · App. 16/483,479 · Granted Apr 9, 2024

Biophotonic methods for increasing in situ energy production and energy emission in biological cells and tissues

Inventors: Nikolaos Loupis (Athens, GR); Remigio Piergallini (San Benedetto del Tronto, IT); David Ohayon (Dollard des Ormeaux, CA); Lise Hébert (Montreal, CA); Giovanni Scapagnini (Catania, IT)
Assignee: FLE INTERNATIONAL S.R.L.
G01N33/48A61B5/0071A61K31/352A61K41/0057A61N5/062A61P17/02
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Quick Facts
Patent No.
US 11,953,493
App. No.
16/483,479
Granted
Apr 9, 2024
Kind
B2
Abstract

The present technology generally relates to a method for modulating in situ production of energy by a biological tissue. The method comprises stimulating the biological tissue by exposing the biological tissue to a photostimulated biophotonic composition for a time sufficient to initiate the production of energy by the biological tissue.

Claims (19)

1. A method for modulating in situ production of energy by a biological tissue, the method comprising stimulating the biological tissue by exposing the biological tissue to a therapeutically effective amount of a photostimulated biophotonic composition for a time sufficient to initiate the production of energy by the biological tissue, wherein the energy is ultra-weak photon emission.

2. The method as defined in claim 1 , wherein the biophotonic composition comprises one or more light-accepting molecules.

3. The method as defined in claim 2 , wherein the one or more light-accepting molecules are xanthene dyes.

4. The method as defined in claim 2 , wherein the one or more light-accepting molecules include Eosin.

5. The method as defined in claim 2 , wherein the one or more light-accepting molecules include Rose Bengal.

6. The method as defined in claim 2 , wherein the biophotonic composition further comprises Reishi.

7. The method as defined in claim 1 , wherein the biophotonic composition further comprises a carbonate salt, or a bicarbonate salt, or both.

8. The method as defined in claim 1 , wherein the biophotonic composition further comprises a carbonate salt.

9. The method as defined in claim 1 , wherein the biophotonic composition further comprises a bicarbonate salt.

10. The method as defined in claim 8 , wherein the carbonate salt is selected from: barium carbonate, beryllium carbonate, caesium carbonate, calcium carbonate, cobalt (II) carbonate, copper (II) carbonate, lithium carbonate, magnesium carbonate, nickel (II) carbonate, potassium carbonate, sodium carbonate, and zinc carbonate.

11. The method as defined in claim 9 , wherein the bicarbonate salt is selected from: ammonium bicarbonate, caesium bicarbonate, potassium bicarbonate, sodium bicarbonate, choline bicarbonate, aminoguanidine bicarbonate, and tetraethylammonium bicarbonate.

12. The method as defined in claim 1 , wherein the biological tissue is a skin tissue.

13. The method as defined in claim 1 , wherein the biological tissue is a population of cells.

14. The method as defined in claim 1 , wherein the photostimulated biophotonic composition emits fluorescence.

15. The method as defined in claim 14 , wherein the fluorescence photostimulates the biological tissue.

16. The method as defined in claim 15 , wherein the photostimulated biological tissue emits photons.

17. The method as defined in claim 1 , wherein the biophotonic composition has a photon emission index of at least 30 seconds.

18. The method as defined in claim 1 , wherein the biophotonic composition has a photon emission index of at least 2 minutes.

19. The method as defined in claim 1 , wherein the biophotonic composition has a photon emission index of at least 30 seconds, or at least 1 minute, or least 2 minutes, or at least 3 minutes, or at least 4 minutes, or at least 5 minutes, or at least 6 minutes, or at least 7 minutes, or at least 8 minutes, or at least 9 minutes, or at least 10 minutes.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 31, 2023
From: KLOX TECHNOLOGIES INC.
To: FLE INTERNATIONAL S.R.L.
Reel/Frame 063214/0370 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2019
From: LOUPIS, NIKOLAOS; PIERGALLINI, REMIGIO; OHAYON, DAVID; HEBERT, LISE; SCAPAGNINI, GIOVANNI
To: KLOX TECHNOLOGIES INC.
Reel/Frame 050008/0008 →
Continuity (2)
Provisional Application 62456246 · Feb 8, 2017
Related Publication 20190360993A1 · Nov 28, 2019