IP Library Granted Patent US 10,780,168
Granted Patent B2
US 10,780,168 · App. 16/484,670 · Granted Sep 22, 2020

Liquid composition containing pradofloxacin

Inventors: Iris Heep (Cologne, DE); Patrick Billian (Brieselang, DE)
Assignee: BAYER ANIMAL HEALTH GMBH
A61K47/20A61K9/0019A61K9/08A61K31/4709A61K47/12A61K47/26
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Quick Facts
Patent No.
US 10,780,168
App. No.
16/484,670
Granted
Sep 22, 2020
Kind
B2
Abstract

The invention relates to pharmaceutical compositions in liquid form comprising pradofloxacin in an aqueous solution and citric acid or thioglycerol as antioxidants.

Claims (20)

1. A liquid composition comprising:

(a) 1 to 30% (w/v) pradofloxacin;

(b) 1 to 30% (w/v) of an acid;

(c) 0.01 to 1% (w/v) of an antioxidant selected from the group consisting of citric acid and thioglycerol;

(d) optionally, one or more pharmaceutical auxiliaries and/or additives and;

(e) water as a solvent.

2. The liquid composition according to claim 1 , wherein the antioxidant is citric acid.

3. The liquid composition according to claim 1 , wherein the antioxidant is thioglycerol.

4. The liquid composition according to claim 2 , wherein the antioxidant is present in a concentration of from 0.05 to 0.5% (w/v).

5. The liquid composition according to claim 4 , wherein the antioxidant is present in a concentration of from 0.05 to 0.3% (w/v).

6. The liquid composition according claim 2 wherein the acid is selected from the group consisting of: gluconic acid, gluconolactone, methanesulfonic acid, lactic acid, and propionic acid.

7. The liquid composition according to claim 6 , wherein the acid is selected from the group consisting of gluconic acid or gluconolactone.

8. The liquid composition according to claim 2 which is a solution.

9. The liquid composition according to claim 2 which has a pH of from 2 to 5.

10. The liquid composition according to claim 3 , wherein the antioxidant is present in a concentration of from 0.05 to 0.5% (w/v).

11. The liquid composition according to claim 10 , wherein the antioxidant is present in a concentration of from 0.05 to 0.3% (w/v).

12. The liquid composition according to claim 3 wherein the acid is selected from the group consisting of: gluconic acid, gluconolactone, methanesulfonic acid, lactic acid, and propionic acid.

13. The liquid composition according to claim 12 wherein the acid is selected from the group consisting of gluconic acid or gluconolactone.

14. The liquid composition according to claim 3 which is a solution.

15. The liquid composition according to claim 3 which has a pH of from 2 to 5.

Assignments (2)
CHANGE OF NAME Recorded Feb 8, 2024
From: BAYER ANIMAL HEALTH GMBH
To: ELANCO ANIMAL HEALTH GMBH
Reel/Frame 066525/0898 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 23, 2019
From: HEEP, IRIS, DR.; BILLIAN, PATRICK, DR.
To: BAYER ANIMAL HEALTH GMBH
Reel/Frame 050152/0658 →