Liquid composition containing pradofloxacin
The invention relates to pharmaceutical compositions in liquid form comprising pradofloxacin in an aqueous solution and citric acid or thioglycerol as antioxidants.
1. A liquid composition comprising:
(a) 1 to 30% (w/v) pradofloxacin;
(b) 1 to 30% (w/v) of an acid;
(c) 0.01 to 1% (w/v) of an antioxidant selected from the group consisting of citric acid and thioglycerol;
(d) optionally, one or more pharmaceutical auxiliaries and/or additives and;
(e) water as a solvent.
2. The liquid composition according to claim 1 , wherein the antioxidant is citric acid.
3. The liquid composition according to claim 1 , wherein the antioxidant is thioglycerol.
4. The liquid composition according to claim 2 , wherein the antioxidant is present in a concentration of from 0.05 to 0.5% (w/v).
5. The liquid composition according to claim 4 , wherein the antioxidant is present in a concentration of from 0.05 to 0.3% (w/v).
6. The liquid composition according claim 2 wherein the acid is selected from the group consisting of: gluconic acid, gluconolactone, methanesulfonic acid, lactic acid, and propionic acid.
7. The liquid composition according to claim 6 , wherein the acid is selected from the group consisting of gluconic acid or gluconolactone.
8. The liquid composition according to claim 2 which is a solution.
9. The liquid composition according to claim 2 which has a pH of from 2 to 5.
10. The liquid composition according to claim 3 , wherein the antioxidant is present in a concentration of from 0.05 to 0.5% (w/v).
11. The liquid composition according to claim 10 , wherein the antioxidant is present in a concentration of from 0.05 to 0.3% (w/v).
12. The liquid composition according to claim 3 wherein the acid is selected from the group consisting of: gluconic acid, gluconolactone, methanesulfonic acid, lactic acid, and propionic acid.
13. The liquid composition according to claim 12 wherein the acid is selected from the group consisting of gluconic acid or gluconolactone.
14. The liquid composition according to claim 3 which is a solution.
15. The liquid composition according to claim 3 which has a pH of from 2 to 5.