Process for the manufacture of SNAC (salcaprozate sodium)
Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid.
1. A method of making a compound of formula:
or an anion or salt thereof, the method comprising the steps of:
i) preparing a reaction mixture comprising a compound of formula:
sodium hydroxide, and one or more of: ethylenediamine tetraacetic acid, ascorbic acid, NaHSO 3 , and triphenylphosphine; and
ii) generating a product mixture comprising an anion or a salt of a compound of formula:
2. The method of claim 1 , wherein the reaction mixture, the product mixture, or both, further comprises water.
3. The method of claim 1 , wherein the reaction mixture, the product mixture, or both, comprises ethylenediamine tetraacetic acid.
4. The method of claim 1 , wherein the reaction mixture, the product mixture, or both, comprises ascorbic acid.
5. The method of claim 1 , wherein the reaction mixture, the product mixture, or both, comprises NaHSO 3 .
6. The method of claim 1 , wherein the reaction mixture, the product mixture, or both, comprises triphenylphosphine.
7. The method of claim 1 , further comprising heating the reaction mixture.
8. The method of claim 1 , further comprising cooling the product mixture.
9. The method of claim 1 , further comprising lowering the pH of the product mixture.
10. The method of claim 1 , further comprising admixing acetone with the product mixture.
11. The method of claim 1 , further comprising admixing HCl with the product mixture.
12. The method of claim 9 , further comprising filtering a solid material from the product mixture, wherein the solid material comprises the compound of formula:
13. The method of claim 12 , further comprising washing the solid material with water.
14. The method of claim 12 , further comprising drying the solid material.