Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.
1. A compound having the formula (I):
or a pharmaceutically acceptable salt or N-oxide derivative thereof.
2. The compound of claim 1 , or a pharmaceutically acceptable salt or N-oxide derivative thereof, and at least one pharmaceutically acceptable excipient.
3. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt or N-oxide derivative thereof, and at least one pharmaceutically acceptable excipient.
4. The pharmaceutical composition of claim 3 comprising one or more further pharmaceutically active agents.
5. A method of treating cancer in a human or animal patient comprising administering to a patient in need thereof an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt or N-oxide derivative thereof, wherein the cancer is selected from the group consisting of colorectal, pancreatic, cervical, ovarian, breast, and non-small cell lung cancers.
6. A method of treating cancer in a human or animal patient comprising administering to a patient in need thereof an effective amount of the pharmaceutical composition according to claim 3 , wherein the cancer is selected from the group consisting of colorectal, pancreatic, cervical, ovarian, breast, and non-small cell lung cancers.
7. The method of claim 5 , wherein the cancer is colorectal cancer.
8. The method of claim 5 , wherein the cancer is non-small cell lung cancer.
9. The method of claim 5 , wherein the cancer is ovarian cancer.
10. The method of claim 6 , wherein the cancer is colorectal cancer.
11. The method of claim 6 , wherein the cancer is non-small cell lung cancer.
12. The method of claim 6 , wherein the cancer is ovarian cancer.