CANNABINOID FORMULATIONS AND DOSAGE
At least one protein-bound cannabinoid bound to a plasma protein for use as a medicament for treatment of a condition, wherein a total cannabinoid dose of the at least one protein-bound cannabinoid, administered over a time period comprising multiple administrations, is lower relative to a total cannabinoid dose of the at least one cannabinoid when administered in unbound form for achieving a same degree of therapeutic effect for treating the condition.
1 - 18 . (canceled)
19 . A method for treating a subject in need thereof, the method comprising administering to the subject an therapeutically effective amount of a composition comprising at least one cannabinoid bound to a plasma protein or portion thereof, in which a total cannabinoid dose of the at least one cannabinoid, administered over a time period comprising multiple administrations, is lower relative to a total cannabinoid dose of the at least one cannabinoid in unbound form for achieving a same degree of therapeutic effect.
20 . The method according to claim 19 , wherein time intervals between administrations of the at least one plasma protein-bound cannabinoid is between about two-fold and about three-fold longer in duration compared to a dosing schedule for achieving the same degree of therapeutic effect with administration of the at least one cannabinoid in unbound form.
21 . The method according to claim 19 , wherein the amount of cannabinoid administered at each of the multiple administrations of the at least one plasma protein-bound cannabinoid is between about 0.7-fold and about 0.5-fold lower compared of the amount of the at least one cannabinoid administered in unbound form.
22 . The method according to claim 19 , wherein the total amount of the at least one cannabinoid administered over the multiple administrations is between one-sixth and one-half relative to the total administered dose of the at least one cannabinoid in unbound form for achieving the same degree of therapeutic effect.
23 . The method according to claim 19 , wherein the at least one cannabinoid is one or a combination of two or more of the group consisting of: THCA, Δ9-THC, Δ8-THC, CBDA, CBD, CBN, CBG, THCV, CBGA, CBC, HU-210, WIN 55,212-2 and JWH-133, and nabilone.
24 . The method according to claim 19 , wherein the plasma protein or portion thereof is selected from the group consisting of: an albumin, a lipoprotein, a glycoprotein, and α, β, and γ globulins, and mixtures of one or more thereof.
25 . The method according to claim 19 , wherein the subject suffers from reduced appetite, the at least one cannabinoid comprises Δ-9THC, and the at least one cannabinoid is administered at a dose of between about 3 mg/week Δ-9-THC and about 9 mg/week Δ-9 THC.
26 . The method according to claim 19 , wherein the subject suffers from nausea, the at least one cannabinoid comprises Δ-9THC, and the at least one cannabinoid is administered at a dose of between about 12 mg/week Δ-9-THC and about 35 mg/week Δ-9 THC.
27 . The method according to claim 19 , wherein the subject suffers from pain associated with fibromyalgia, the at least one cannabinoid comprises nabilone, and the at least one cannabinoid is administered at a dose of between about 2 mg/week nabilone and about 7 mg/week nabilone.
28 . The method according to claim 19 , wherein the subject suffers from chronic pain, the at least one cannabinoid comprises nabilone, and the at least one cannabinoid is administered at a dose of between about 0.6 mg/week nabilone and about 1.75 mg/week nabilone.
29 . The method according to claim 28 , wherein the chronic pain is associated with one or more of fibromyalgia, upper motor neuron syndrome, and central pain syndrome.
30 . The method according to claim 19 , wherein the subject suffers from chronic pain associated with cancer, the at least one cannabinoid comprises THC, and the at least one cannabinoid is administered at a dose of between about 6 mg/week THC and about 17.5 mg/week THC.
31 . The method according to claim 19 , wherein the subject suffers from epilepsy, the at least one cannabinoid comprises CBD, and the at least one cannabinoid is administered at a dose of between about 233 mg/week CBD and about 700 mg/week CBD.
32 . The method according to claim 19 , wherein the subject suffers from epilepsy, the at least one cannabinoid comprises CBD, and the at least one cannabinoid is administered at a dose of between about 5.5 mg/kg/week CBD and about 17.5 mg/kg/week CBD.
33 . The method according to claim 19 , wherein the subject suffers from epilepsy associated with Dravet Syndrome or Lennox-Gastaut Syndrome, the at least one cannabinoid comprises CBD, and the at least one cannabinoid is administered at a dose of between about 23 mg/kg/week CBD and about 70 mg/kg/week CBD.
34 . The method according to claim 19 , wherein the subject suffers from epilepsy, the at least one cannabinoid comprises CBD and THC, and the at least one cannabinoid is administered at a dose of between about 3.2 mg/week THC with about 2.9 mg/week CBD and about 9.5 mg/week THC with about 8.7 mg/week CBD.
35 . The method according to claim 19 , wherein the subject suffers from chronic pain, the at least one cannabinoid comprises CBD and THC, and the at least one cannabinoid is administered at a dose of between about 3.2 mg/week THC with about 2.9 mg/week CBD and about 9.5 mg/week THC with about 8.7 mg/week CBD.
36 . The method according the claim 35 , wherein the chronic pain is associated with one or more of a nerve lesion, rheumatoid arthritis, a cancer, and multiple sclerosis.