9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.
1. A compound of formula XX:
or a pharmaceutically acceptable salt thereof, wherein:
T is —NH— or —O—;
R is hydrogen or an optionally substituted C 1-6 aliphatic;
R 1 is methyl;
R 2 is halogen, —CN, —SR y , —S(O) 2 R y , —SO 2 R y , —OSO 2 R y , —OC(O)R y , or —OP(O) 2 OR y ; and
each R y is independently selected from optionally substituted C 1-6 aliphatic or optionally substituted phenyl.
2. The compound according to claim 1 , wherein T is —O—.
3. The compound according to claim 1 , wherein T is —NH—.
4. The compound according to claim 1 , wherein R 2 is halogen.
5. The compound according to claim 1 , wherein R 2 is —SR y or —SO 2 R y .
6. A pharmaceutically acceptable composition comprising the compound according to claim 1 and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
7. The compound according to claim 4 , wherein R 2 is fluoro or chloro.
8. The compound according to claim 4 , wherein R 2 is chloro.
9. The compound according to claim 2 , wherein R 2 is chloro.
10. The compound according to claim 1 , wherein R is C 1-6 aliphatic substituted with oxo, halogen, —CN, (CH 2 ) 0-4 R ∘ , —(CH 2 ) 0-4 OR ∘ , or —(CH 2 ) 0-4 S(O) 2 R ∘ , wherein R ∘ is C 1- 6 aliphatic.
11. The compound according to claim 9 , wherein R is C 1-6 aliphatic substituted with oxo, halogen, —CN, —(CH 2 ) 0-4 R ∘ , —(CH 2 ) 0-4 OR ∘ , or —(CH 2 ) 0-4 S(O) 2 R ∘ , wherein R ∘ is C 1-6 aliphatic.
12. The compound according to claim 1 , wherein the compound is selected from:
or a pharmaceutically acceptable salt thereof.
13. The compound according to claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
14. A pharmaceutically acceptable composition comprising the compound according to claim 11 and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
15. A pharmaceutically acceptable composition comprising the compound according to claim 12 and a pharmaceutically acceptable carrier, adjuvant, or vehicle.