Systems and methods for manufacturing and safety of an NO

1. A reactor cartridge for converting NO 2 to NO for delivery to a patient using a gas delivery system, comprising:

an outer reactor shell;

an inlet end wall that seals the inlet end of the reactor;

an outlet end wall that seals the outlet end of the reactor to form an internal volume within the reactor cartridge;

an inlet that facilitates connection of the reactor cartridge to a first gas conduit and allows passage of gas through the inlet end wall to the internal volume;

an outlet that facilitates connection of the reactor cartridge to a second gas conduit and allows passage of gas through the outlet end wall to exit the reactor cartridge;

a consumable conversion media retained within the internal volume of the reactor cartridge that facilitates conversion of an incoming NO 2 gas delivered to the inlet to an outgoing NO gas exiting at the outlet for delivery to the patient;

a back end retainer positioned towards the outlet of the reactor cartridge to prevent consumable conversion media from exiting the internal volume of the reactor cartridge through the outlet;

a front end retainer positioned towards the inlet of the reactor cartridge to prevent consumable conversion media from exiting the internal volume of the reactor cartridge through the inlet, wherein the consumable conversion media is retained between the front end retainer and the back end retainer;

a force-applying member positioned between the inlet end wall and the front end retainer to apply a pressure to the consumable conversion media; and

a memory chip affixed to the outer reactor shell, wherein the memory chip stores data relating to the conversion cartridge that the chip is affixed to on a non-transient computer readable medium, wherein the stored data comprises identification data, testing data, and cartridge life data, wherein the memory chip is configured to be in electronic communication with a computer and wherein the computer is configured to read the stored data and prevent the gas delivery system from entering an operational state if the identification data, testing data, or cartridge life data exceeds a stored average expected identification data, testing data, or cartridge life data, wherein the identification data includes a cartridge serial number, a lot and/or batch number, a production date, and/or an expiration date, the testing data includes a weight of consumable conversion media within the conversion cartridge, values of test results showing conversion efficiency of NO 2 to NO, pressure drop across the consumable conversion media, and/or a humidity level of the consumable conversion media, and the cartridge life data includes average expected cartridge life calculated from the testing data, total expected NO 2 conversion by weight, concentration, and/or volume, and/or expected duration of usage at an average gas flow rate.

2. The reactor cartridge of claim 1 , which further comprises an impact sensor affixed to and/or operatively associated with the reactor cartridge, wherein the impact sensor is configured to determine the number of impacts and/or the severity of the impact(s) experienced by the reactor cartridge.

3. The reactor cartridge of claim 1 , which further comprises an inlet with a keyed or polarized cartridge connector and/or an outlet with a keyed or polarized cartridge connector, wherein the keyed or polarized inlet and/or outlet connectors interact with a mechanical interlock to ensure the reactor cartridge is installed with the correct orientation in a gas delivery system.