IP Library Granted Patent US 12,007,458
Granted Patent B2
US 12,007,458 · App. 16/504,455 · Granted Jun 11, 2024

Magnetic resonance imaging apparatus and magnetic resonance imaging method

Inventors: Mitsue Miyazaki (Des Plaines, IL); Christine Chung (Oakland, CA)
Assignees: CANON MEDICAL SYSTEMS CORPORATION; The Regents of the University of California
G01R33/4828A61B5/055G01R33/50G01R33/543G01R33/546
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Quick Facts
Patent No.
US 12,007,458
App. No.
16/504,455
Granted
Jun 11, 2024
Kind
B2
Abstract

A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and processing circuitry. The sequence controlling circuitry acquires a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value, to acquire a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, and to acquire a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values. The processing circuitry extracts a signal related to water, a signal related to a first fat, and a signal related to a second fat, on the basis of the first piece of data, the second piece of data, and the third piece of data.

Claims (89)

1. A magnetic resonance imaging apparatus, comprising:

sequence controlling circuitry configured to acquire a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value, to acquire a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, and to acquire a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat, and wherein the second pulse sequence is executed such that the second TE value causes a signal of protons of a first fat and a signal of protons of a second fat to have phases opposite to each other; and

processing circuitry configured to extract a signal related to water, a signal related to the first fat, and a signal related to the second fat, based on the first piece of data, the second piece of data, and the third piece of data, and based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat;

wherein the sequence controlling circuitry is further configured to

execute the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

execute the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

execute the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

the sequence controlling circuitry is configured to execute only three pulse sequences, which are the first pulse sequence, the second pulse sequence, and the third pulse sequence.

2. The magnetic resonance imaging apparatus according to claim 1 , wherein the sequence controlling circuitry is further configured to execute the first pulse sequence, the second pulse sequence, and the third pulse sequence as a linked one acquisition while maintaining a receiver gain at a same level.

3. The magnetic resonance imaging apparatus according to claim 1 , wherein the processing circuitry is further configured to extract the signal related to the water, the signal related to the first fat, and the signal related to the second fat, based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat.

4. The magnetic resonance imaging apparatus according to claim 1 , wherein the sequence controlling circuitry is further configured to execute the first pulse sequence, the second pulse sequence, and the third pulse sequence such that the center frequency is equal to the frequency corresponding to a chemical shift of the fat, wherein the fat is aliphatic fat.

5. The magnetic resonance imaging apparatus according to claim 1 , wherein the processing circuitry is further configured to generate one selected from between a two-dimensional image and a three-dimensional image, based on the signal related to the water, the signal related to the first fat, and the signal related to the second fat.

6. The magnetic resonance imaging apparatus according to claim 1 , wherein

the processing circuitry is further configured to receive, from a user, an input indicating types of the first fat and the second fat and, based on a result of the received input, and establish a setting about the first pulse sequence, the second pulse sequence, and the third pulse sequence, and

the sequence controlling circuitry is further configured to execute the first pulse sequence, the second pulse sequence, and the third pulse sequence, while maintaining a receiver gain at a same level.

7. The magnetic resonance imaging apparatus according to claim 1 , wherein

the processing circuitry is further configured to receive, from a user, an input indicating a plurality of types of fat including an input indicating types of the first fat and the second fat and, based on a result of the received input, and establish a setting about three or more pulse sequences including the first pulse sequence, the second pulse sequence, and the third pulse sequence,

the sequence controlling circuitry is further configured to execute the three or more pulse sequences, and

the processing circuitry is further configured to extract signals each related to a different one of the plurality of types of fat, based on pieces of data obtained from the three or more pulse sequences executed by the sequence controlling circuitry.

8. A magnetic resonance imaging method implemented by a magnetic resonance imaging apparatus, the method comprising:

acquiring a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value; acquiring a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, wherein the second TE value causes a signal of protons of a first fat and a signal of protons of a second fat to have phases opposite to each other;

acquiring a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat; and

extracting a signal related to water, a signal related to the first fat, and a signal related to the second fat, based on the first piece of data, the second piece of data, and the third piece of data, and based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat;

wherein the method further comprises

executing the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

executing the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

executing the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other; and

the method comprises executing only three pulse sequences, which are the first pulse sequence, the second pulse sequence and the third pulse sequence.

9. The magnetic resonance imaging method according to claim 7 , wherein the fat is aliphatic fat.

10. A magnetic resonance imaging apparatus, comprising:

sequence controlling circuitry configured to acquire a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value, to acquire a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, and to acquire a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat; and

processing circuitry configured to extract a signal related to water, a signal related to a first fat, and a signal related to a second fat, based on the first piece of data, the second piece of data, and the third piece of data, and based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat;

wherein the second pulse sequence is executed such that the second TE value causes a signal of aliphatic protons and a signal of olefinic fat protons to have phases opposite to each other;

the sequence controlling circuitry is further configured to

execute the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

execute the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

execute the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other; and

the sequence controlling circuitry is configured to execute only three pulse sequences, which are the first pulse sequence, the second pulse sequence, and the third pulse sequence.

11. A magnetic resonance imaging apparatus, comprising:

sequence controlling circuitry configured to acquire a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value, to acquire a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, and to acquire a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat; and

processing circuitry configured to extract a signal related to water, a signal related to a first fat, and a signal related to a second fat, based on the first piece of data, the second piece of data, and the third piece of data, and based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat;

wherein the second pulse sequence is executed such that the second TE value causes a signal of aliphatic protons and a signal of unsaturated fat protons to have phases opposite to each other;

the sequence controlling circuitry is further configured to

execute the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

execute the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

execute the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other; and

the sequence controlling circuitry is configured to execute only three pulse sequences, which are the first pulse sequence, the second pulse sequence, and the third pulse sequence.

12. A magnetic resonance imaging apparatus, comprising:

sequence controlling circuitry configured to acquire a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value, to acquire a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, and to acquire a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat; and

processing circuitry configured to extract a signal related to water, a signal related to a first fat, and a signal related to a second fat, based on the first piece of data, the second piece of data, and the third piece of data, and based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat;

wherein the second pulse sequence is executed such that the second TE value causes a signal of aliphatic protons and a signal of polyunsaturated fat protons to have phases opposite to each other;

the sequence controlling circuitry is further configured to

execute the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

execute the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

execute the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other; and

the sequence controlling circuitry is configured to execute only three pulse sequences, which are the first pulse sequence, the second pulse sequence, and the third pulse sequence.

13. A magnetic resonance imaging method implemented by a magnetic resonance imaging apparatus, the method comprising:

acquiring a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value;

acquiring a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value;

acquiring a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat; and

extracting a signal related to water, a signal related to a first fat, and a signal related to a second fat, based on the first piece of data, the second piece of data, and the third piece of data,

wherein the second pulse sequence is executed such that the second TE value causes a signal of aliphatic protons and a signal of olefinic fat protons to have phases opposite to each other, based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat; and

the method further comprises

executing the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

executing the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

executing the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other; and

the method comprises executing only three pulse sequences, which are the first pulse sequence, the second pulse sequence and the third pulse sequence.

14. A magnetic resonance imaging method implemented by a magnetic resonance imaging apparatus, the method comprising:

acquiring a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value;

acquiring a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value;

acquiring a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat; and

extracting a signal related to water, a signal related to a first fat, and a signal related to a second fat, based on the first piece of data, the second piece of data, and the third piece of data, and based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat;

wherein the second pulse sequence is executed such that the second TE value causes a signal of aliphatic protons and a signal of unsaturated fat protons to have phases opposite to each other;

the method further comprises

executing the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

executing the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

executing the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other; and

the method comprises executing only three pulse sequences, which are the first pulse sequence, the second pulse sequence and the third pulse sequence.

15. A magnetic resonance imaging method implemented by a magnetic resonance imaging apparatus, the method comprising:

acquiring a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value;

acquiring a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value;

acquiring a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values, wherein the first pulse sequence, the second pulse sequence, and the third pulse sequence are executed such that a center frequency is equal to a frequency corresponding to a chemical shift of a fat; and

extracting a signal related to water, a signal related to a first fat, and a signal related to a second fat, based on the first piece of data, the second piece of data, and the third piece of data, and based on values of a chemical shift of the water, a chemical shift of the first fat, and a chemical shift of the second fat;

wherein the second pulse sequence is executed such that the second TE value causes a signal of aliphatic protons and a signal of polyunsaturated fat protons to have phases opposite to each other;

the method further comprises

executing the first pulse sequence by using the first TE value that causes a signal of the first fat and a signal of the second fat to be in-phase with each other,

executing the second pulse sequence by using the second TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other, and

executing the third pulse sequence by using the third TE value that causes the signal of the first fat and the signal of the second fat to be out of phase with each other; and

the method comprises executing only three pulse sequences, which are the first pulse sequence, the second pulse sequence and the third pulse sequence.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 1, 2026
From: CANON MEDICAL SYSTEMS CORPORATION
To: CANON KABUSHIKI KAISHA
Reel/Frame 075315/0598 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2023
From: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
To: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, OFFICE OF THE GENERAL COUNSEL (024); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 063839/0898 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2020
From: CHUNG, CHRISTINE
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 053720/0092 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2020
From: MIYAZAKI, MITSUE
To: CANON MEDICAL SYSTEMS CORPORATION
Reel/Frame 053732/0630 →