Creatine oral supplementation using creatine hydrochloride salt
The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
1. A nutritional supplement comprising:
creatine hydrochloride having, an aqueous solubility of at least about 150 mg/mL in water at 25° C. after a time period of about 1.5 hours; and
L-glutamine.
2. The nutritional supplement of claim 1 , wherein the creatine hydrochloride has an aqueous solubility of at least about 240 mg/mL or greater in water at 25° C. after a time period of about 1.5 hours.
3. The nutritional supplement of claim 1 , wherein the creatine hydrochloride has an aqueous solubility of at least about 600 mg/mL in water at 25° C. after a time period of about 1.5 hours.
4. The nutritional supplement of claim 1 , wherein the L-glutamine is present in an amount of about 100 mg to about 500 mg per dose.
5. The nutritional supplement of claim 1 , further comprising HMB, ribose, or a combination thereof.
6. The nutritional supplement of claim 1 , comprised in an oral dosage form.
7. A nutritional supplement comprising:
creatine hydrochloride having an aqueous solubility in water at 25° C. after a time period of about 1.5 hours of at least an order of magnitude greater than creatine monohydrate; and
L-glutamine.
8. The nutritional supplement of claim 7 , further comprising at least one additive comprising one or more proteins, amino acid supplements, carbohydrates, D-Ribose, fats, fiber, sweeteners, flavoring agents, or combinations thereof.
9. The nutritional supplement of claim 7 , further comprising HMB, ribose, or a combination thereof.
10. The nutritional supplement of claim 7 , comprised in an oral dosage form.
11. The nutritional supplement of claim 8 , wherein the at least one additive is a sweetener selected from the group consisting of sucralose, aspartame, saccharin, acesulfame potassium, neohesperidin dihydrochalcone, glycyrrhizin, thaumatin, alitame, stevioside, and combinations thereof.
12. The nutritional supplement of claim 11 , further comprising a flavoring agent selected from the group consisting of cocoa, yogurt, peanut butter, mint, cheesecake, hazelnut paste, almonds, granola, coconut, strawberry, banana, cherry, plum, raspberry, lemon, orange, lime, pineapple, blueberry and other fruit flavors, coffee, cremes, jellies, and combinations thereof.
13. A nutritional supplement comprising:
creatine hydrochloride having an aqueous solubility of at least about 150 mg/mL in water at 25° C. after a time period of about 1.5 hours; and
at least one additive comprising L-glutamine, HMB, ribose, or a combination thereof.
14. The nutritional supplement of claim 13 , wherein the creatine hydrochloride has an aqueous solubility of at least about 240 mg/mL or greater in water at 25° C. after a time period of about 1.5 hours.
15. The nutritional supplement of claim 13 , wherein the at least one additive is present in an amount of about 100 mg to about 500 mg per dose.
16. The nutritional supplement of claim 15 , further comprising one or more proteins, amino acid supplements, carbohydrates, D-Ribose, fats, fiber, sweeteners, flavoring agents, or combinations thereof.
17. The nutritional supplement of claim 13 , wherein the creatine hydrochloride has an aqueous solubility of at least 480 mg/mL in water at 25° C. after a time period of about 1.5 hours.
18. The nutritional supplement of claim 1 , wherein the creatine hydrochloride has an aqueous solubility of at least about 650 mg/mL in water at 25° C. after a time period of about 1.5 hours.
19. The nutritional supplement of claim 7 , wherein the creatine hydrochloride has an aqueous solubility of at least about 650 mg/mL in water at 25° C. after a time period of about 1.5 hours.
20. The nutritional supplement of claim 13 , wherein the creatine hydrochloride has an aqueous solubility of at least about 650 mg/mL in water at 25° C. after a time period of about 1.5 hours.