METHODS AND COMPOSITIONS FOR INHIBITING CD32B EXPRESSING CELLS
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
1 - 20 . (canceled)
21 . A method of inducing dendritic cell proliferation in a patient in need thereof comprising:
administering to the patient an effective amount of anti-human CD40 antibody comprising a light chain and a heavy chain, the heavy chain comprising a human IgG1 Fc domain comprising a S267E amino acid substitution, wherein the numbering is according to the EU index as in Kabat, thereby inducing dendritic cell proliferation in the patient.
22 . A method of activating B cells in a patient in need thereof comprising:
administering to the patient an effective amount of anti-human CD40 antibody comprising a light chain and a heavy chain, the heavy chain comprising a human IgG1 Fc domain comprising a S267E amino acid substitution, wherein the numbering is according to the EU index as in Kabat, thereby activating B cells in the patient.