Method for forming hydrogels and materials therefor

1. A dry powder mixture comprising:

a non-crosslinked prepolymer comprising a straight chain polyethylene glycol; and

a thermally activated free radical initiator selected from the group consisting of sodium persulfate, potassium persulfate, and ammonium persulfate

wherein the dry powder mixture is characterized by a particle size of about 500 microns or less, and

wherein the dry power mixture is stable at ambient conditions.

2. The dry powder of claim 1 ;

wherein the dry powder may be transported at ambient temperature from one location to another location for a period of time without degrading;

wherein the dry powder may be mixed into a polymerizable solution; and

wherein the dry powder is terminally sterilized.

3. The dry powder of claim 1 , wherein the dry powder is selected from the group consisting of a lyophilized powder, dry blended powder, and spray dried powder.

4. The dry powder of claim 1 , wherein the dry powder is a lyophilized powder.

5. The dry powder of claim 1 , wherein the straight chain polyethylene glycol is terminally derivatized with acrylate, methacrylate, vinyl, or substituted vinyl end groups.

6. The dry powder of claim 1 , wherein the prepolymer is characterized by a molecular weight of about 1 to 100 kiloDaltons.

7. The dry powder of claim 1 , further comprising a buffer selected from the group consisting of phosphate, sodium phosphate dibasic, and sodium phosphate monobasic.

8. The dry powder of claim 1 , further comprising a radiopaque agent.

9. The dry powder of claim 1 , wherein the dry powder is a lyophilized powder comprising:

the prepolymer comprising a straight chain polyethylene glycol, wherein the straight chain polyethylene glycol is terminally derivatized with two acrylate groups, and wherein the prepolymer is characterized by a molecular weight of about 1 to 100 kiloDaltons;

the thermally activated free radical initiator selected from the group consisting of sodium persulfate, potassium persulfate, and ammonium persulfate;

a phosphate buffer; and

a sodium diatrizoate radiopaque agent, wherein the dry powder is characterized by a stable composition at ambient conditions.

10. A dry powder mixture comprising

a first non-crosslinked prepolymer comprising a straight chain polyethylene glycol, wherein the straight chain polyethylene glycol is terminally derivatized with two acrylate groups; and

a thermally activated free radical initiator selected from the group consisting of sodium persulfate, potassium persulfate, and ammonium persulfate;

wherein the dry powder is characterized by a particle size of about 500 microns or less, wherein the dry powder is further characterized by a stable composition at ambient conditions,

and wherein the dry powder forms a hydrogel under suitable conditions when combined with a buffered aqueous solution comprising:

a second prepolymer comprising a branched chain oligomeric polyethylene glycol; and an initiator catalyst.

11. The dry powder of claim 10 , further comprising a radiopaque agent.

12. The dry powder of claim 10 , wherein the dry powder is lyophilized powder, dry blended powder or a spray dried powder.

13. A kit comprising:

a first container comprising a dry powder mixture comprising a non-cross linked straight chain polyethylene glycol terminally derivatized with two acrylate groups, and a thermally activated free radical initiator comprising a persulfate, wherein the dry powder mixture is characterized by a particle size of about 500 microns or less, and

wherein the dry power mixture is stable at ambient conditions;

a second container comprising a branched chain oligomeric polyethylene glycol; and

a third container comprising an initiator catalyst and a buffer;

wherein the combination of the first, second and third container contents forms a hydrogel under suitable conditions.