Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
1. A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
2. The compound of claim 1 , wherein the compound is in the form of a hydrochloride salt.
3. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 3 , wherein the compound is in the form of a hydrochloride salt.
5. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 5 , wherein the compound is in the form of a hydrochloride salt.
7. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 7 , wherein the compound is in the form of a hydrochloride salt.
9. A pharmaceutical composition, comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
10. A pharmaceutical composition, comprising the compound of claim 3 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
11. A pharmaceutical composition, comprising the compound of claim 5 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
12. A pharmaceutical composition, comprising the compound of claim 7 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.