PRKC fusions
The invention provides PRKC gene fusions, PRKC fusion proteins, and fragments of those genes and polypeptides. The invention further provides methods of diagnosing and treating diseases or disorders associated with PRKC fusions, such as conditions mediated by aberrant PRKC expression or activity, or overexpression of PRKC.
1. A method of detecting in a patient a TANC2:PRKCA fusion, said method comprising:
a) contacting a biological sample from the patient with an oligonucleotide that hybridizes to or amplifies the TANC2:PRKCA fusion of SEQ ID NO:3 or a portion thereof comprising a fusion junction; and
b) detecting (i) binding between the TANC2:PRKCA fusion and the oligonucleotide or (ii) detecting amplification of the TANC2:PRKCA fusion.
2. The method of claim 1 , wherein the oligonucleotide hybridizes under stringent conditions to:
a) a fragment of SEQ ID NO:3 comprising nucleotides 134-146 of SEQ ID NO:3; or
b) a complementary oligonucleotide of a).
3. The method of claim 1 , wherein the patient is suffering from or susceptible to a cancer.
4. The method of claim 3 , wherein the cancer is lung cancer.
5. The method of claim 3 , wherein the cancer is lung squamous cell carcinoma or lung adenocarcinoma.
6. The method of claim 5 , wherein the cancer is lung squamous cell carcinoma.
7. The method of claim 5 , wherein the cancer is lung adenocarcinoma.