Bodily fluid sample collection and transport
Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.
1. A method comprising:
receiving, in a channel, a bodily fluid sample provided by a subject;
mixing the bodily fluid sample with an anticoagulant to generate a mixed bodily fluid sample; and
collecting, in a vessel in fluid communication with the channel, the mixed bodily fluid sample,
wherein the anticoagulant comprises EDTA, and wherein the mixed bodily fluid sample comprises a bulk concentration of EDTA no less than about 2.5 milligrams per milliliter and no greater than about 10 milligrams per milliliter, wherein a concentration of the anticoagulant coating varies along a length of the channel according to a gradient.
2. The method of claim 1 , wherein mixing the bodily fluid sample with the anticoagulant comprises mixing the bodily fluid sample with the anticoagulant without generating a local concentration of EDTA greater than about 1121110 milligrams per milliliter.
3. The method of claim 1 , wherein the mixed bodily fluid sample reaches the bulk concentration of EDTA at a time less than 90 seconds after the bodily fluid sample was initially received in the channel.
4. A method comprising:
receiving, in a channel, a bodily fluid sample provided by a subject;
mixing the bodily fluid sample with an anticoagulant to generate a mixed bodily fluid sample; and
collecting, in a vessel in fluid communication with the channel, the mixed bodily fluid sample,
wherein the anticoagulant comprises heparin, and wherein the mixed bodily fluid sample comprises a bulk concentration of heparin no less than about 20 units per milliliter and no greater than about 150 units per milliliter, wherein a thickness of the anticoagulant coating varies along a length of the channel according to a gradient.
5. The method of claim 4 , wherein the mixed bodily fluid sample reaches the bulk concentration of heparin at a time less than 90 seconds after the bodily fluid sample was initially received in the channel.
6. The method of claim 4 , wherein mixing the bodily fluid sample with the anticoagulant comprises mixing the bodily fluid sample with the anticoagulant with a shear rate no greater than about 1,000 reciprocal seconds.
7. A method comprising:
receiving, in a channel, a bodily fluid sample provided by a subject;
mixing the bodily fluid sample with an anticoagulant to generate a mixed bodily fluid sample; and
collecting, in a vessel in fluid communication with the channel, the mixed bodily fluid sample,
wherein the anticoagulant comprises EDTA, and wherein the mixed bodily fluid sample comprises a bulk concentration of EDTA no less than about 2.5 milligrams per milliliter and no greater than about 10 milligrams per milliliter, wherein a concentration of the anticoagulant coating varies along a length of the channel according to a gradient;
wherein mixing the bodily fluid sample with the anticoagulant comprises mixing the bodily fluid sample with the anticoagulant with a shear rate no greater than about 1,000 reciprocal seconds.