IP Library Granted Patent US 10,987,347
Granted Patent B1
US 10,987,347 · App. 16/517,926 · Granted Apr 27, 2021

Pharmaceutical compositions and methods of using the same

Inventors: Jeffrey M. Moshal (Allentown, PA); Michael Libman (Allentown, PA)
Assignee: GENUS LIFESCIENCES INC.
A61K31/46A61B1/233A61B1/267A61K9/0014A61K9/0019A61K9/0043A61K31/573A61K47/12
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Quick Facts
Patent No.
US 10,987,347
App. No.
16/517,926
Granted
Apr 27, 2021
Kind
B1
Abstract

Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.

Claims (14)

1. A method for induction of local anesthesia prior to performing a medical procedure on, through, or adjacent to a mucous membrane of a nasal cavity of a patient comprising:

determining a Child-Pugh score for a patient;

soaking a plurality of absorbent articles in an aqueous solution comprising, by weight, about 3.6% to about 4.4% cocaine hydrochloride, about 0.07% to about 0.20% sodium benzoate, and citric acid; and

contacting at least one of the plurality of absorbent articles with a mucous membrane of the patient for up to about 20 minutes to reduce sensation in a body region of the patient, if the patient has a Grade A Child-Pugh score.

2. The method of claim 1 , wherein the aqueous solution further comprises at least one coloring additive.

3. A method for induction of local anesthesia prior to performing a medical procedure on, through, or adjacent to a mucous membrane of a nasal cavity of a patient comprising:

determining a Child-Pugh score for a patient;

soaking a plurality of absorbent articles in an aqueous solution comprising, by weight, about 3.6% to about 4.4% cocaine hydrochloride, about 0.07% to about 0.20% sodium benzoate, and citric acid; and

contacting at least one of the plurality of absorbent articles with a mucous membrane of the patient for up to about 20 minutes to reduce sensation in a body region of the patient, if the patient has a Grade A or Grade B Child-Pugh score.

4. The method of claim 3 , wherein the aqueous solution further comprises at least one coloring additive.

5. The method of claim 1 , wherein the aqueous solution comprises about 0.125% citric acid.

6. The method of claim 3 , wherein the aqueous solution comprises about 0.125% citric acid.

7. The method of claim 1 , wherein a pH of the aqueous solution is 2 to 4.

8. The method of claim 3 , wherein a pH of the aqueous solution is 2 to 4.

Assignments (4)
SECURITY INTEREST Recorded Apr 27, 2026
From: LXO IRELAND DESIGNATED ACTIVITY COMPANY
To: KROLL TRUSTEE SERVICES LIMITED, AS SECURITY AGENT
Reel/Frame 074483/0163 →
CHANGE OF NAME Recorded Dec 10, 2025
From: NODEN PHARMA DESIGNATED ACTIVITY COMPANY
To: LXO IRELAND DESIGNATED ACTIVITY COMPANY
Reel/Frame 073940/0952 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2023
From: GENUS LIFESCIENCES INC.
To: NODEN PHARMA DESIGNATED ACTIVITY COMPANY
Reel/Frame 062999/0559 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2019
From: MOSHAL, JEFFREY M.; LIBMAN, MICHAEL
To: GENUS LIFESCIENCES INC.
Reel/Frame 049821/0304 →
Continuity (4)
Division 15935776 · Mar 26, 2018
Continuation 15849575 · Dec 20, 2017
Continuation 15470133 · Mar 27, 2017
Continuation 15427011 · Feb 7, 2017
Cited By (1)
US 12,508,256