Pharmaceutical compositions and methods of using the same
Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.
1. A method for induction of local anesthesia prior to performing a medical procedure on, through, or adjacent to a mucous membrane of a nasal cavity of a patient comprising:
determining a Child-Pugh score for a patient;
soaking a plurality of absorbent articles in an aqueous solution comprising, by weight, about 3.6% to about 4.4% cocaine hydrochloride, about 0.07% to about 0.20% sodium benzoate, and citric acid; and
contacting at least one of the plurality of absorbent articles with a mucous membrane of the patient for up to about 20 minutes to reduce sensation in a body region of the patient, if the patient has a Grade A Child-Pugh score.
2. The method of claim 1 , wherein the aqueous solution further comprises at least one coloring additive.
3. A method for induction of local anesthesia prior to performing a medical procedure on, through, or adjacent to a mucous membrane of a nasal cavity of a patient comprising:
determining a Child-Pugh score for a patient;
soaking a plurality of absorbent articles in an aqueous solution comprising, by weight, about 3.6% to about 4.4% cocaine hydrochloride, about 0.07% to about 0.20% sodium benzoate, and citric acid; and
contacting at least one of the plurality of absorbent articles with a mucous membrane of the patient for up to about 20 minutes to reduce sensation in a body region of the patient, if the patient has a Grade A or Grade B Child-Pugh score.
4. The method of claim 3 , wherein the aqueous solution further comprises at least one coloring additive.
5. The method of claim 1 , wherein the aqueous solution comprises about 0.125% citric acid.
6. The method of claim 3 , wherein the aqueous solution comprises about 0.125% citric acid.
7. The method of claim 1 , wherein a pH of the aqueous solution is 2 to 4.
8. The method of claim 3 , wherein a pH of the aqueous solution is 2 to 4.