IP Library › Granted Patent US 11,071,784
Granted Patent B2
US 11,071,784 · App. 16/520,183 · Granted Jul 27, 2021

Biodegradable lipids for the delivery of active agents

Inventors: Martin Maier (Cambridge, MA); Muthusamy Jayaraman (Cambridge, MA); Akin Akinc (Cambridge, MA); Shigeo Matsuda (Cambridge, MA); Pachamuthu Kandasamy (Cambridge, MA); Kallanthottathil G. Rajeev (Cambridge, MA); Muthiah Manoharan (Cambridge, MA)
Assignee: ALNYLAM PHARMACEUTICALS, INC.
A61K47/18A61K9/1272A61K9/5123A61K31/7088A61K31/713A61K31/7105C07C31/125C07C211/09C07C211/10C07C211/11C07C217/08C07C229/12C07C235/06C07C251/38C07C323/12C07C323/58C07C327/22C07C327/28C07C327/32C07D207/32C07D233/54C07D295/08C07D295/12C07D295/14C07D317/30C07F5/022
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Quick Facts
Patent No.
US 11,071,784
App. No.
16/520,183
Granted
Jul 27, 2021
Kind
B2
Abstract

The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Claims (1)

1. The compound

Assignments (3)
SECURITY INTEREST Recorded Oct 1, 2025
From: ALNYLAM PHARMACEUTICALS, INC.; SIRNA THERAPEUTICS, INC.
To: BANK OF AMERICA, N.A.
Reel/Frame 072996/0337 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 1, 2022
From: MAIER, MARTIN; JAYARAMAN, MUTHUSAMY; AKINC, AKIN; MATSUDA, SHIGEO; KANDASAMY, PACHAMUTHU; RAJEEV, KALLANTHOTTATHIL G; MANOHARAN, MUTHIAH
To: ALNYLAM PHARMACEUTICALS, INC.
Reel/Frame 060971/0051 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2021
From: MAIER, MARTIN; JAYARAMAN, MUTHUSAMY; AKINC, AKIN; MATSUDA, SHIGEO; KANDASAMY, PACHAMUTHU; RAJEEV, KALLANTHOTTATHIL G; MANOHARAN, MUTHIAH
To: ALNYLAM PHARMACEUTICALS, INC.
Reel/Frame 058140/0101 →