Pneumococcal dosing regimen
Methods of immunizing older adult subjects against Streptococcus pneumoniae infection are provided. Provided methods comprise immunization of naïve adult subjects with a conjugated pneumococcal polysaccharide vaccine. Optionally, initial immunization may be followed by additional immunization doses comprising conjugated pneumococcal polysaccharide vaccine or unconjugated pneumococcal polysaccharide vaccine composition.
1. A method of immunizing against a Streptococcus pneumoniae -caused disease in a subject who is at least 50 years of age, said method comprising administering to said subject an immunogenic amount of a pneumococcal polysaccharide conjugate vaccine by a method selected from intramuscular, intradermal, subcutaneous, and intranasal delivery, wherein said pneumococcal polysaccharide conjugate vaccine comprises polysaccharides of serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, wherein said method further comprises administering to said subject an immunogenic amount of a 23-valent pneumococcal unconjugated polysaccharide vaccine, and wherein said 23-valent pneumococcal unconjugated polysaccharide vaccine is administered to said subject at least one year after administering said pneumococcal polysaccharide conjugate vaccine.
2. The method of claim 1 , wherein each of said polysaccharides is conjugated to a polypeptide carrier, wherein said polypeptide carrier is selected from the group consisting of the meningococcal outer membrane protein complex, the CRM 197 variant of diphtheria toxin, diphtheria toxoid, tetanus toxoid, cholera toxoid, pertussis toxoid, inactivated or mutant pneumococcal pneumolysin, pneumococcal surface protein A or a derivative thereof, pneumococcal adhesion protein A or a derivative thereof, C5a peptidase group a or group b streptococcus or a derivative thereof, non-typable H. influenzae P4 protein or a derivative thereof, non-typable H. influenzae P6 protein or a derivative thereof, M. catarrhalis uspA or a derivative thereof, Keyhole Limpet Haemocyanin (KLH), protein derivative of Tuberculin (PPD), protein D from H. influenzae , and OMPC of N. meningitidis.
3. The method of claim 2 , wherein said polypeptide carrier is the CRM 197 variant of diphtheria toxin.
4. The method of claim 1 , wherein said pneumococcal polysaccharide conjugate vaccine comprises 2 μg of each polysaccharide, except for 6B at 4 μg.
5. The method of claim 1 , wherein said subject has never previously received said pneumococcal polysaccharide conjugate vaccine or said 23-valent pneumococcal unconjugated polysaccharide vaccine.
6. The method of claim 1 , wherein administration of said 23-valent pneumococcal unconjugated polysaccharide vaccine at least one year after administering said pneumococcal polysaccharide conjugate vaccine elicits an immunoprotective antibody response.
7. The method of claim 6 , wherein said immunoprotective antibody response for serotypes 4, 6B, 9V, 14, 18C, and 23F is higher relative to administration of said 23-valent pneumococcal unconjugated polysaccharide vaccine alone.