Crystalline forms of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate
This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.
1. A method of treating a hematologic malignancy in a mammal having said hematologic malignancy, comprising administering to the mammal a therapeutically effective amount of a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, having the structure:
and having a powder X-ray diffraction pattern comprising peaks at 2θ values of: 11.6, 12.1 and 19.6 °2θ±0.2 °2θ.
2. A method of treating a hematologic malignancy in a mammal having said hematologic malignancy, comprising administering to the mammal a therapeutically effective amount of a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, having the structure:
and having: (a) a powder X-ray diffraction pattern comprising peaks at 2θ values of: 11.6 and 12.1 °2θ±0.2 °2θ; and (b) a Raman spectrum comprising wavenumber (cm −1 ) values of: 1612 and 2219 cm −1 ±2 cm −1 .
3. A method of treating a hematologic malignancy in a mammal having said hematologic malignancy, comprising administering to the mammal a therapeutically effective amount of a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, having the structure:
and having: (a) a powder X-ray diffraction pattern comprising peaks at 28 values of: 11.6 and 12.1 °2θ±0.2 °2θ; (b) a Raman spectrum comprising wavenumber (cm −1 ) values of: 1612 and 2219 cm −1 ±2 cm −1 ; and (c) a 13 C solid state NMR spectrum comprising a resonance (ppm) value of: 148.3 ppm±0.2 ppm.
4. A method of treating a hematologic malignancy in a mammal having said hematologic malignancy, comprising administering to the mammal a therapeutically effective amount of a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, having the structure:
and having: (a) a powder X-ray diffraction pattern comprising peaks at 2θ values of: 11.6 and 12.1 °2θ±0.2 °2θ; and (b) a 13 C solid state NMR spectrum comprising a resonance (ppm) value of: 148.3 ppm±0.2 ppm.
5. The method of claim 1 , wherein the mammal is a human.
6. The method of claim 2 , wherein the mammal is a human.
7. The method of claim 3 , wherein the mammal is a human.
8. The method of claim 4 , wherein the mammal is a human.
9. The method of claim 1 , wherein the hematologic malignancy is selected from the group consisting of acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelomonocytic leukemia, myelofibrosis and myelodysplastic syndrome.
10. The method of claim 2 , wherein the hematologic malignancy is selected from the group consisting of acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelomonocytic leukemia, myelofibrosis and myelodysplastic syndrome.
11. The method of claim 3 , wherein the hematologic malignancy is selected from the group consisting of acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelomonocytic leukemia, myelofibrosis and myelodysplastic syndrome.
12. The method of claim 4 , wherein the hematologic malignancy is selected from the group consisting of acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelomonocytic leukemia, myelofibrosis and myelodysplastic syndrome.
13. The method of claim 1 , wherein the hematologic malignancy is acute myeloid leukemia.
14. The method of claim 2 , wherein the hematologic malignancy is acute myeloid leukemia.
15. The method of claim 3 , wherein the hematologic malignancy is acute myeloid leukemia.
16. The method of claim 4 , wherein the hematologic malignancy is acute myeloid leukemia.
17. The method of claim 1 , wherein the hematologic malignancy is acute lymphoblastic leukemia.
18. The method of claim 2 , wherein the hematologic malignancy is acute lymphoblastic leukemia.
19. The method of claim 3 , wherein the hematologic malignancy is acute lymphoblastic leukemia.
20. The method of claim 4 , wherein the hematologic malignancy is acute lymphoblastic leukemia.
21. The method of claim 1 , wherein the hematologic malignancy is chronic myelomonocytic leukemia.
22. The method of claim 2 , wherein the hematologic malignancy is chronic myelomonocytic leukemia.
23. The method of claim 3 , wherein the hematologic malignancy is chronic myelomonocytic leukemia.
24. The method of claim 4 , wherein the hematologic malignancy is chronic myelomonocytic leukemia.
25. The method of claim 1 , wherein the hematologic malignancy is myelofibrosis.
26. The method of claim 2 , wherein the hematologic malignancy is myelofibrosis.
27. The method of claim 3 , wherein the hematologic malignancy is myelofibrosis.
28. The method of claim 4 , wherein the hematologic malignancy is myelofibrosis.
29. The method of claim 1 , wherein the hematologic malignancy is myelodysplastic syndrome.
30. The method of claim 2 , wherein the hematologic malignancy is myelodysplastic syndrome.
31. The method of claim 3 , wherein the hematologic malignancy is myelodysplastic syndrome.
32. The method of claim 4 , wherein the hematologic malignancy is myelodysplastic syndrome.