System and method for controlling the harshness of nicotine-based dry powder formulations
A method of controlling or electing the harshness of inhaled nicotine powder formulations is described. The method includes the steps of identifying a concentration of nicotine for a subject to inhale to achieve a desired level of harshness per inhalation, identifying the total dose of nicotine to be inhaled by the subject, and providing the subject with an amount of a formulation comprising nicotine particles having the identified concentration of nicotine, such that the total amount of nicotine particles in the formulation equals the total dose of nicotine.
1. A method of controlling the harshness of nicotine inhaled by a subject, the method comprising the steps of:
identifying a concentration of nicotine for a dry powder formulation comprising nicotine particles for a subject to inhale based on a desired level of harshness per inhalation, the nicotine particles comprising nicotine salt and sugar;
providing the subject with a first dose comprising a first amount of the formulation having the identified concentration of nicotine;
providing the subject with a second dose comprising a second amount of the formulation, the second dose comprising a lower amount of nicotine than the first dose; and
providing the subject with a third dose comprising a third amount of the formulation, the third dose comprising a lower amount of nicotine than the second dose,
wherein at least one of the second and third doses has a concentration that is higher than the identified concentration of the first dose to increase the harshness of the nicotine inhaled by the subject.
2. The method of claim 1 , wherein the identified concentration of nicotine is selected from concentrations ranging from 0.7 wt-% to 10 wt-%.
3. The method of claim 1 , wherein the method is a method of smoking cessation therapy.
4. The method of claim 1 , wherein the nicotine particles comprise trehalose.
5. The method of claim 1 , wherein the nicotine particles are less than 5 micron in size.
6. The method of claim 1 , wherein the formulation further comprises cough suppressant particles.
7. The method of claim 1 , wherein the formulation is delivered to a subject via a dry powder inhaler.
8. A method of delivering reducing dosages of nicotine to a subject by inhalation, the method comprising:
identifying a first concentration of nicotine for a nicotine dry powder formulation to achieve a desired first level of harshness per inhalation, the nicotine dry powder formulation comprising nicotine particles comprising nicotine salt and sugar;
providing a first dose to the subject, the first dose comprising the nicotine dry powder formulation having the identified first concentration of nicotine;
providing a second dose to the subject, the second dose being lower than the first dose and having a second concentration of nicotine which is greater than the first concentration of nicotine; and
providing a third dose to the subject, the third dose being lower than the second dose and having a third concentration of nicotine which is greater than the second concentration of nicotine.
9. The method of claim 8 , wherein the identified concentration of nicotine is selected from concentrations ranging from 0.7 wt-% to 10 wt-%.
10. The method of claim 8 , wherein the method is a method of smoking cessation therapy.
11. The method of claim 8 , wherein the nicotine particles further comprise trehalose.
12. The method of claim 8 , wherein the nicotine particles are less than 5 micron in size.
13. The method of claim 8 , wherein the formulation further comprises cough suppressant particles.
14. The method of claim 8 , wherein the formulation is delivered to a subject via a dry powder inhaler.