System for inducing desirable temperature effects on body tissue
A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands.
1. A system, comprising:
a catheter body having a proximal end and a distal end with an axis therebetween;
a balloon supported by the distal end of the catheter body, the balloon having a low profile insertion configuration and a larger profile configuration;
a plurality of flex circuits attached to the balloon and defining a plurality of remodeling zones that extend about a circumference of a body lumen when the balloon is in the larger profile configuration, each flex circuit comprising a pair of electrodes on a flexible substrate, the flexible circuits being sufficiently flexible to allow folding and inflation of the balloon; and
a power source configured to electrically couple with the electrodes of the flex circuits, and to transmit a tissue remodeling energy between the electrodes of the pairs,
wherein the power source is further configured to transmit the tissue remodeling energy to each of the plurality of remodeling zones such that the tissue remodeling energy transmitted to remodeling zones including both a target tissue and a collateral tissue heats the target tissue sufficiently to efficaciously alter the target tissue without causing thermal damage to the collateral tissue;
wherein each of the flexible circuits includes an associated bipolar electrode pair;
wherein the bipolar electrode pairs are configured to be energized with RF energy;
wherein the bipolar electrode pairs have adjacent edge-to-edge spacings of between 0.25 mm and 2.50 mm; and
wherein the bipolar electrode pairs are configured to provide a load impedance of from 20 to 4500 Ohms when delivering tissue remodeling energy to the target tissues.
2. The system of claim 1 , wherein the power source is configured to energize the pairs of electrodes with about 0.25 to 20 Watts average power for a duration between 1 to 180 seconds or wherein the power source s configured to energize the pairs of electrodes so as to deliver 8 to 45 Joules of energy in a treatment.
3. The system of claim 1 , wherein the system is configured to affect controlled delivery of the tissue remodeling energy using a characteristic of the target tissue measured with one or more of the pairs of electrodes or wherein the power source is configured to energize the pairs of electrodes so as to deliver 8 to 45 Joules of energy in a treatment.
4. The system of claim 3 , wherein the characteristic comprises a load impedance.
5. The system of claim 1 , wherein the target tissue has a specific conductivity within a range from 0.2 to 0.5 Siemens per meter.