IP Library Granted Patent US 11,467,239
Granted Patent B2
US 11,467,239 · App. 16/524,598 · Granted Oct 11, 2022

Deep learning techniques for magnetic resonance image reconstruction

Inventors: Jo Schlemper (Long Island City, NY); Seyed Sadegh Mosheni Salehi (Bloomfield, NJ); Michal Sofka (Princeton, NJ); Prantik Kundu (Branford, CT); Ziyi Wang (Durham, NC); Carole Lazarus (Paris, FR); Hadrien A. Dyvorne (New York, NY); Laura Sacolick (Guilford, CT); Rafael O'Halloran (Guilford, CT); Jonathan M. Rothberg (Miami Beach, FL)
Assignee: Hyperfine Operations, Inc.
G01R33/5608G01R33/561G06F17/142G06F17/18G06N3/0454G06N3/08G06T11/006G06T2210/41
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,467,239
App. No.
16/524,598
Granted
Oct 11, 2022
Kind
B2
Abstract

A magnetic resonance imaging (MRI) system, comprising: a magnetics system comprising: a B 0 magnet configured to provide a B 0 field for the MRI system; gradient coils configured to provide gradient fields for the MRI system; and at least one RF coil configured to detect magnetic resonance (MR) signals; and a controller configured to: control the magnetics system to acquire MR spatial frequency data using non-Cartesian sampling; and generate an MR image from the acquired MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform data consistency processing using a non-uniform Fourier transformation.

Claims (63)

1. A method, comprising:

generating a magnetic resonance (MR) image from input MR spatial frequency data using a neural network model that comprises:

a first neural network sub-model configured to process spatial frequency domain data; and

a second neural network sub-model configured to process image domain data;

wherein the generating comprises:

processing the input MR spatial frequency data using the first neural network sub-model to obtain output MR spatial frequency data;

transforming the output MR spatial frequency data to the image domain to obtain input image-domain data; and

processing the input image-domain data using the second neural network sub-model to obtain the MR image.

2. The method of claim 1 ,

wherein the first neural network sub-model includes at least one convolutional layer, a locally-connected layer, and at least one transposed convolutional layer, and

wherein processing the input MR spatial frequency data using the first neural network sub-model comprises:

applying the at least one convolutional layer to the input MR spatial frequency data;

applying the locally-connected layer to data obtained using output of the at least one convolutional layer; and

applying the at least one transposed convolutional layer to data obtained using output of the locally-connected layer.

3. The method of claim 2 , wherein the first neural network sub-model includes a complex-conjugate symmetry layer, and wherein processing the input MR spatial frequency data using the first neural network sub-model comprises:

applying the complex-conjugate symmetry layer to data obtained using output of the at least one transposed convolutional layer.

4. The method of claim 2 , wherein the first neural network sub-model includes a data consistency layer, and wherein processing the input MR spatial frequency data using the first neural network sub-model comprises:

applying the data consistency layer to data obtained using output of the complex-conjugate symmetry layer.

5. The method of claim 1 , wherein the first neural network sub-model includes at least one convolutional layer and at least one transposed convolutional layer.

6. The method of claim 1 , wherein the first neural network sub-model includes at least one locally-connected layer.

7. The method of claim 1 , wherein the first neural network sub-model includes at least one data consistency layer.

8. The method of claim 1 , wherein the first neural network sub-model comprises a data consistency block implemented at least in part using a non-uniform fast Fourier transform and the second neural network sub-model comprises a convolutional neural network block.

9. The method of claim 1 , wherein the first neural network sub-model includes at least one fully-connected layer.

10. The method of claim 1 , wherein the first neural network sub-model includes a fully-connected layer, the method further comprising:

applying the fully-connected layer to a real part of the spatial frequency domain data; and

applying the fully-connected layer to an imaginary part of the spatial frequency domain data.

11. The method of claim 1 , wherein the first neural network sub-model includes a first fully-connected and a second fully connected layer, the method further comprising:

applying the first fully-connected layer to a real part of the spatial frequency domain data;

applying the second fully-connected layer to an imaginary part of the spatial frequency domain data.

12. The method of claim 11 , wherein the first and second fully-connected layers share at least some weights.

13. The method of claim 11 , further comprising:

transforming output of the first and second fully-connected layers using a Fourier transformation to obtain image-domain data; and

providing the image-domain data as input to the second neural network sub-model.

14. The method of claim 1 , wherein the second neural network sub-model comprises a series of blocks comprising respective sets of neural network layers, each of the plurality of blocks comprising at least one convolutional layer and at least one transposed convolutional layer.

15. The method of claim 14 , wherein each of the plurality of blocks further comprises: a Fourier transformation layer, a data consistency layer, and an inverse Fourier transformation layer.

16. The method of claim 1 , further comprising:

training the neural network model using a set of high-field images to obtain a first trained neural network model; and

adapting the first neural network model by using a set of low-field images.

17. The method of claim 1 , wherein the spatial frequency domain data is under-sampled relative to a Nyquist criterion.

18. A system, comprising:

at least one computer hardware processor; and

at least one non-transitory computer-readable storage medium storing processor-executable instructions that, when executed by the at least one computer hardware processor, cause the at least one computer hardware processor to perform:

generating a magnetic resonance (MR) image from MR spatial frequency data using a neural network model that comprises:

a first neural network portion configured to process data in a spatial frequency domain; and

a second neural network portion configured to process data in an image domain;

wherein the generating comprises:

processing the MR spatial frequency data using the first neural network portion to obtain output MR spatial frequency data;

transforming the output MR spatial frequency data to the image domain to obtain input image-domain data; and

processing the input image-domain data using the second neural network portion to obtain the MR image.

19. A magnetic resonance imaging (MRI) system, comprising:

a magnetics system comprising:

a B 0 magnet configured to provide a B 0 field for the MRI system;

gradient coils configured to provide gradient fields for the MRI system; and

at least one RF coil configured to detect magnetic resonance (MR) signals;

a controller configured to:

control the magnetics system to acquire MR spatial frequency data;

generate an MR image from MR spatial frequency data using a neural network model that comprises:

a first neural network portion configured to process data in a spatial frequency domain; and

a second neural network portion configured to process data in an image domain;

wherein the generating comprises:

processing the MR spatial frequency data using the first neural network portion to obtain output MR spatial frequency data;

transforming the output MR spatial frequency data to the image domain to obtain input image-domain data; and

processing the input image-domain data using the second neural network portion to obtain the MR image.

Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE SECOND INVENTOR NAME SHOULD BE CORRECTED TO RE SEYED SADEGH MOHSENI SALEHI PREVIOUSLY RECORDED AT REEL: 054977 FRAME: 0224. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 19, 2022
From: SCHLEMPER, JO; SALEHI, SEYED SADEGH MOHSENI; KUNDO, PRANTIK; WANG, ZIYI; LAZARUS, CAROLE; DYVORNE, HADRIEN A.; SACOLICK, LAURA; O'HALLORAN, RAFAEL; ROTHBERG, JONATHAN M.
To: HYPERFINE RESEARCH, INC.
Reel/Frame 060728/0094 →
CHANGE OF NAME Recorded Mar 7, 2022
From: HYPERFINE, INC.
To: HYPERFINE OPERATIONS, INC.
Reel/Frame 059332/0615 →
CHANGE OF NAME Recorded Jun 29, 2021
From: HYPERFINE RESEARCH, INC.
To: HYPERFINE, INC.
Reel/Frame 056715/0901 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2021
From: 4CATALYZER CORPORATION
To: HYPERFINE RESEARCH, INC.
Reel/Frame 054906/0462 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2021
From: SCHLEMPER, JO; MOSHEN SALEHI, SEYED SADEGH; KUNDU, PRANTIK; WANG, ZIYI; LAZARUS, CAROLE; DYVORNE, HADRIEN A.; SACOLICK, LAURA; O'HALLORAN, RAFAEL; ROTHBERG, JONATHAN M.
To: HYPERFINE RESEARCH, INC.
Reel/Frame 054977/0224 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2021
From: SOFKA, MICHAL
To: 4CATALYZER CORPORATION
Reel/Frame 054977/0310 →
Continuity (5)
Provisional Application 62820119 · Mar 18, 2019
Provisional Application 62744529 · Oct 11, 2018
Provisional Application 62737524 · Sep 27, 2018
Provisional Application 62711895 · Jul 30, 2018
Related Publication 20200034998A1 · Jan 30, 2020
Cited By (1)
US 12,265,911