IP Library Granted Patent US 11,300,645
Granted Patent B2
US 11,300,645 · App. 16/524,638 · Granted Apr 12, 2022

Deep learning techniques for magnetic resonance image reconstruction

Inventors: Jo Schlemper (Long Island City, NY); Seyed Sadegh Moshen Salehi (Bloomfield, NJ); Michal Sofka (Princeton, NJ); Prantik Kundu (Branford, CT); Ziyi Wang (Durham, NC); Carole Lazarus (Paris, FR); Hadrien A. Dyvorne (New York, NY); Laura Sacolick (Guilford, CT); Rafael O'Halloran (Guilford, CT); Jonathan M. Rothberg (Miami Beach, FL)
Assignee: Hyperfine Operations, Inc.
G01R33/5608G01R33/561G06F17/142G06F17/18G06N3/0454G06N3/08G06T11/006G06T2210/41
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Quick Facts
Patent No.
US 11,300,645
App. No.
16/524,638
Granted
Apr 12, 2022
Kind
B2
Abstract

A magnetic resonance imaging (MRI) system, comprising: a magnetics system comprising: a B 0 magnet configured to provide a B 0 field for the MRI system; gradient coils configured to provide gradient fields for the MRI system; and at least one RF coil configured to detect magnetic resonance (MR) signals; and a controller configured to: control the magnetics system to acquire MR spatial frequency data using non-Cartesian sampling; and generate an MR image from the acquired MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform data consistency processing using a non-uniform Fourier transformation.

Claims (56)

1. A method, comprising:

generating a magnetic resonance (MR) image from input MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform processing using a non-uniform Fourier transformation for transforming image domain data to spatial frequency domain data; and

applying the first neural network block to image domain data, wherein the applying comprises:

applying, to the image domain data, the non-uniform Fourier transformation followed by an adjoint non-uniform Fourier transformation to obtain first output;

applying the adjoint non-uniform Fourier transformation to the input MR spatial frequency data to obtain second output; and

providing the image domain data, the first output, and the second output as inputs to a plurality of convolutional layers.

2. The method of claim 1 , wherein each of the one or more neural network blocks is configured to perform processing using the non-uniform Fourier transformation.

3. The method of claim 1 , further comprising:

obtaining the input MR spatial frequency data;

generating an initial image from the input MR spatial frequency data using the non-uniform Fourier transformation; and

applying the neural network model to the initial image at least in part by using the first neural network block to perform the processing using the non-uniform Fourier transformation.

4. The method of claim 1 , wherein the first neural network block is configured to perform processing using the non-uniform Fourier transformation at least in part by performing the non-uniform Fourier transformation on data by applying a gridding interpolation transformation, a Fourier transformation, and a de-apodization transformation to the data.

5. The method of claim 4 , wherein applying the gridding interpolation transformation to the data is performed using sparse graphical processing unit (GPU) matrix multiplication.

6. The method of claim 1 , wherein the first neural network block comprises:

the plurality of convolutional layers.

7. The method of claim 6 , wherein the plurality of convolutional layers include one or more convolutional layers and one or more transposed convolutional layers.

8. The method of claim 6 , wherein the plurality of convolutional layers have a U-net structure.

9. The method of claim 1 , wherein the plurality of convolutional layers is configured to generate the MR image using the image domain data, the first output, and the second output.

10. The method of claim 1 , further comprising:

applying a convolutional neural network to a result of applying the non-uniform Fourier transformation to the image domain data to obtain an intermediate output; and

applying the adjoint non-uniform Fourier transformation to the intermediate output to obtain the first output.

11. The method of claim 1 , wherein points in the input MR spatial frequency data were obtained using a non-Cartesian sampling trajectory.

12. The method of claim 11 , wherein the non-uniform Fourier transformation is determined at least in part by using the non-Cartesian sampling trajectory.

13. At least one non-transitory computer-readable storage medium storing processor-executable instructions that, when executed by at least one computer hardware processor, cause the at least one computer hardware processor to perform a method comprising:

generating a magnetic resonance (MR) image from input MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform processing using a non-uniform Fourier transformation for transforming image domain data to spatial frequency domain data; and

applying the first neural network block to image domain data, wherein the applying comprises:

applying, to the image domain data, the non-uniform Fourier transformation followed by an adjoint non-uniform Fourier transformation to obtain first output;

applying the adjoint non-uniform Fourier transformation to the input MR spatial frequency data to obtain second output; and

providing the image domain data, the first output, and the second output as inputs to a plurality of convolutional layers.

14. The at least one non-transitory computer-readable storage medium of claim 13 , wherein the method further comprises:

obtaining the input MR spatial frequency data;

generating an initial image from the input MR spatial frequency data using the non-uniform Fourier transformation; and

applying the neural network model to the initial image at least in part by using the first neural network block to perform the processing using the non-uniform Fourier transformation.

15. The at least one non-transitory computer-readable storage medium of 13 , wherein applying the first neural network block further comprises:

performing processing using the non-uniform Fourier transformation at least in part by performing the non-uniform Fourier transformation on data by applying a gridding interpolation transformation, a Fourier transformation, and a de-apodization transformation to the data.

16. The at least one non-transitory computer-readable storage medium of 13 , wherein the method further comprises:

applying a convolutional neural network to a result of applying the non-uniform Fourier transformation to the image domain data to obtain an intermediate output; and

applying the adjoint non-uniform Fourier transformation to the intermediate output to obtain the first output.

17. A magnetic resonance imaging (MRI) system, comprising:

a magnetics system comprising:

a B 0 magnet configured to provide a B 0 field for the MRI system;

gradient coils configured to provide gradient fields for the MRI system;

at least one RF coil configured to detect magnetic resonance (MR) signals; and

a controller configured to:

control the magnetics system to acquire MR spatial frequency data using a non-Cartesian sampling trajectory;

generate an MR image from the acquired MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform processing using a non-uniform Fourier transformation; and

apply the first neural network block to image domain data, wherein the applying comprises:

applying, to the image domain data, the non-uniform Fourier transformation followed by an adjoint non-uniform Fourier transformation to obtain first output;

applying the adjoint non-uniform Fourier transformation to the input MR spatial frequency data to obtain second output; and

providing the image domain data, the first output, and the second output as inputs to a plurality of convolutional layers.

18. The MRI system of claim 17 , wherein the B 0 magnet is a permanent magnet.

19. The MRI system of claim 17 , wherein the controller is further configured to:

obtain the input MR spatial frequency data;

generate an initial image from the input MR spatial frequency data using the non-uniform Fourier transformation; and

apply the neural network model to the initial image at least in part by using the first neural network block to perform the processing using the non-uniform Fourier transformation.

20. The MRI system of claim 17 , wherein the first neural network block is configured to perform processing using the non-uniform Fourier transformation at least in part by performing the non-uniform Fourier transformation on data by applying a gridding interpolation transformation, a Fourier transformation, and a de-apodization transformation to the data.

Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE SECOND INVENTOR NAME SHOULD BE CORRECTED TO RE SEYED SADEGH MOHSENI SALEHI PREVIOUSLY RECORDED AT REEL: 054977 FRAME: 0224. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 19, 2022
From: SCHLEMPER, JO; SALEHI, SEYED SADEGH MOHSENI; KUNDO, PRANTIK; WANG, ZIYI; LAZARUS, CAROLE; DYVORNE, HADRIEN A.; SACOLICK, LAURA; O'HALLORAN, RAFAEL; ROTHBERG, JONATHAN M.
To: HYPERFINE RESEARCH, INC.
Reel/Frame 060728/0094 →
CHANGE OF NAME Recorded Mar 2, 2022
From: HYPERFINE, INC.
To: HYPERFINE OPERATIONS, INC.
Reel/Frame 059293/0385 →
CHANGE OF NAME Recorded Jun 29, 2021
From: HYPERFINE RESEARCH, INC.
To: HYPERFINE, INC.
Reel/Frame 056715/0901 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2021
From: 4CATALYZER CORPORATION
To: HYPERFINE RESEARCH, INC.
Reel/Frame 054906/0462 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2021
From: SCHLEMPER, JO; MOSHEN SALEHI, SEYED SADEGH; KUNDU, PRANTIK; WANG, ZIYI; LAZARUS, CAROLE; DYVORNE, HADRIEN A.; SACOLICK, LAURA; O'HALLORAN, RAFAEL; ROTHBERG, JONATHAN M.
To: HYPERFINE RESEARCH, INC.
Reel/Frame 054977/0224 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2021
From: SOFKA, MICHAL
To: 4CATALYZER CORPORATION
Reel/Frame 054977/0310 →
Continuity (5)
Provisional Application 62820119 · Mar 18, 2019
Provisional Application 62744529 · Oct 11, 2018
Provisional Application 62737524 · Sep 27, 2018
Provisional Application 62711895 · Jul 30, 2018
Related Publication 20200033431A1 · Jan 30, 2020
Cited By (5)
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