IP Library Granted Patent US 10,874,461
Granted Patent B2
US 10,874,461 · App. 16/528,263 · Granted Dec 29, 2020

Systems and methods for determining and visualizing a functional relationship between a vascular network and perfused tissue

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Quick Facts
Patent No.
US 10,874,461
App. No.
16/528,263
Granted
Dec 29, 2020
Kind
B2
Abstract

Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

Claims (95)

1. A computer-implemented method for displaying information of a functional relationship between a vasculature and a perfused tissue, the method comprising:

receiving a patient-specific vascular model of a patient's anatomy;

receiving a patient-specific tissue model of the patient's anatomy, the patient-specific tissue model describing a tissue supplied at least in part with blood through a vasculature described by the patient-specific vascular model;

generating a user interface comprising a display of at least a portion of the patient-specific vascular model and a display of at least a portion of the patient-specific tissue model;

receiving, via the user interface, a selection indicating a portion of a first model, the first model being one of the patient-specific vascular model and the patient-specific tissue model, the indicated portion of the first model having a blood supply relationship with an associated portion of a second model, the second model being another of the patient-specific vascular model and the patient-specific tissue model; and

upon receiving the selection of the portion of the first model, displaying, in the user interface:

the portion of the second model in a manner indicating that the associated portion of the second model has the blood supply relationship with the indicated portion of the first model, or

a blood supply estimate inside or near one of the indicated portion of the first model and the associated portion of the second model.

2. The computer-implemented method of claim 1 , wherein

the first model is the patient-specific vascular model,

the indicated portion of the first model represents a portion of the vasculature,

the second model is the patient-specific tissue model, and

the blood supply relationship is a relationship in which the associated portion of the second model represents a portion of the tissue supplied by blood passing through the portion of the vasculature.

3. The computer-implemented method of claim 2 , wherein

the displaying displays the associated portion of the second model in a manner indicating that the associated portion of the second model has the blood supply relationship with the indicated portion of the first model, and

the associated portion of the second model is a region of a geometrical model of the patient-specific tissue model or a region of a bulls-eye model of the patient-specific tissue model.

4. The computer-implemented method of claim 2 , wherein

the displaying displays the blood supply estimate inside or near the indicated portion of the first model,

the blood supply estimate is an estimate of a blood supply in the vasculature, and

the method comprises, prior to the displaying, determining the estimate of blood supply in the vasculature based on the patient-specific vascular model.

5. The computer-implemented method of claim 2 , wherein

the displaying displays the blood supply estimate inside or near the associated portion of the second model,

the blood supply estimate is an estimate of a blood supply in the tissue, and

the method comprises, prior to the displaying, determining the estimate of blood supply in the tissue based on the patient-specific tissue model.

6. The computer-implemented method of claim 1 , wherein

the first model is the patient-specific tissue model,

the indicated portion of the first model represents a portion of the tissue,

the second model is the patient-specific vascular model, and

the blood supply relationship is a relationship in which the associated portion of the second model represents a location of the vasculature that supplies blood to the portion of the tissue.

7. The computer-implemented method of claim 6 , wherein

the displaying displays the associated portion of the second model in a manner indicating that the associated portion of the second model has the blood supply relationship with the indicated portion of the first model, and

the indicated portion of the first model is a region of a geometrical model of the patient-specific tissue model or a region of a bulls-eye model of the patient-specific tissue model.

8. The computer-implemented method of claim 1 , wherein

the displaying displays the blood supply estimate inside or near the one of the indicated portion of the first model and the associated portion of the second model, and

the blood supply estimate is a blood pressure, a blood flow, a blood flow rate, or a blood speed.

9. A system for displaying information of a functional relationship between a vasculature and a perfused tissue, the system comprising:

at least one data storage device storing instructions for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue; and

at least one processor configured to execute the instructions to perform a method including:

receiving a patient-specific vascular model of a patient's anatomy;

receiving a patient-specific tissue model of the patient's anatomy, the patient-specific tissue model describing a tissue supplied at least in part with blood through a vasculature described by the patient-specific vascular model;

generating a user interface comprising a display of at least a portion of the patient-specific vascular model and a display of at least a portion of the patient-specific tissue model;

receiving, via the user interface, a selection indicating a portion of a first model, the first model being one of the patient-specific vascular model and the patient-specific tissue model, the indicated portion of the first model having a blood supply relationship with an associated portion of a second model, the second model being another of the patient-specific vascular model and the patient-specific tissue model; and

upon receiving the selection of the portion of the first model, displaying, in the user interface:

the portion of the second model in a manner indicating that the associated portion of the second model has the blood supply relationship with the indicated portion of the first model, or

a blood supply estimate inside or near one of the indicated portion of the first model and the associated portion of the second model.

10. The system of claim 9 , wherein

the first model is the patient-specific vascular model,

the indicated portion of the first model represents a portion of the vasculature,

the second model is the patient-specific tissue model, and

the blood supply relationship is a relationship in which the associated portion of the second model represents a portion of the tissue supplied by blood passing through the portion of the vasculature.

11. The system of claim 10 , wherein

the displaying displays the associated portion of the second model in a manner indicating that the associated portion of the second model has the blood supply relationship with the indicated portion of the first model, and

the associated portion of the second model is a region of a geometrical model of the patient-specific tissue model or a region of a bulls-eye model of the patient-specific tissue model.

12. The system of claim 10 , wherein

the displaying displays the blood supply estimate inside or near the indicated portion of the first model,

the blood supply estimate is an estimate of a blood supply in the vasculature, and

the method comprises, prior to the displaying, determining the estimate of blood supply in the vasculature based on the patient-specific vascular model.

13. The system of claim 10 , wherein

the displaying displays the blood supply estimate inside or near the associated portion of the second model,

the blood supply estimate is an estimate of a blood supply in the tissue, and

the method comprises, prior to the displaying, determining the estimate of blood supply in the tissue based on the patient-specific tissue model.

14. The system of claim 10 , wherein

the first model is the patient-specific tissue model,

the indicated portion of the first model represents a portion of the tissue,

the second model is the patient-specific vascular model, and

the blood supply relationship is a relationship in which the associated portion of the second model represents a location of the vasculature that supplies blood to the portion of the tissue.

15. A non-transitory computer-readable medium storing operations for displaying information of a functional relationship between a vasculature and a perfused tissue, the operations comprising:

receiving a patient-specific vascular model of a patient's anatomy;

receiving a patient-specific tissue model of the patient's anatomy, the patient-specific tissue model describing a tissue supplied at least in part with blood through a vasculature described by the patient-specific vascular model;

generating a user interface comprising a display of at least a portion of the patient-specific vascular model and a display of at least a portion of the patient-specific tissue model;

receiving, via the user interface, a selection indicating a portion of a first model, the first model being one of the patient-specific vascular model and the patient-specific tissue model, the indicated portion of the first model having a blood supply relationship with an associated portion of a second model, the second model being another of the patient-specific vascular model and the patient-specific tissue model; and

upon receiving the selection of the portion of the first model, displaying, in the user interface:

the portion of the second model in a manner indicating that the associated portion of the second model has the blood supply relationship with the indicated portion of the first model, or

a blood supply estimate inside or near one of the indicated portion of the first model and the associated portion of the second model.

16. The computer-readable medium of claim 15 , wherein

the first model is the patient-specific vascular model,

the indicated portion of the first model represents a portion of the vasculature,

the second model is the patient-specific tissue model, and

the blood supply relationship is a relationship in which the associated portion of the second model represents a portion of the tissue supplied by blood passing through the portion of the vasculature.

17. The computer-readable medium of claim 16 , wherein

the displaying displays the associated portion of the second model in a manner indicating that the associated portion of the second model has the blood supply relationship with the indicated portion of the first model, and

the associated portion of the second model is a region of a geometrical model of the patient-specific tissue model or a region of a bulls-eye model of the patient-specific tissue model.

18. The computer-readable medium of claim 16 , wherein

the displaying displays the blood supply estimate inside or near the indicated portion of the first model,

the blood supply estimate is an estimate of a blood supply in the vasculature, and

the method comprises, prior to the displaying, determining the estimate of blood supply in the vasculature based on the patient-specific vascular model.

19. The computer-readable medium of claim 16 , wherein

the displaying displays the blood supply estimate inside or near the associated portion of the second model,

the blood supply estimate is an estimate of a blood supply in the tissue, and

the method comprises, prior to the displaying, determining the estimate of blood supply in the tissue based on the patient-specific tissue model.

20. The computer-readable medium of claim 15 , wherein

the first model is the patient-specific tissue model,

the indicated portion of the first model represents a portion of the tissue,

the second model is the patient-specific vascular model, and

the blood supply relationship is a relationship in which the associated portion of the second model represents a location of the vasculature that supplies blood to the portion of the tissue.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Sep 11, 2025
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 072876/0775 →
RELEASE OF SECURITY INTEREST Recorded Jun 21, 2024
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 067801/0032 →
SECURITY INTEREST Recorded Jun 18, 2024
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 067775/0966 →
SECURITY INTEREST Recorded Jan 20, 2021
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 055037/0890 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2019
From: JAQUET, CLARA; SCHAAP, MICHIEL; BAI, YING; GRADY, LEO J.; TAYLOR, CHARLES A.
To: HEARTFLOW, INC.
Reel/Frame 050112/0147 →