TRISPECIFIC ANTIBODIES

1 . A trispecific antibody comprising:

a) a first monomer comprising a first heavy chain comprising a first variant Fc domain and a first variable heavy domain;

b) a second monomer comprising:

i) a second variant Fc domain;

ii) a first scFv domain; and

c) a light chain comprising a constant light domain and a variable light domain;

wherein the first variable heavy domain and the first variable light domain form an antigen binding domain, and

wherein one of the first and second monomers further comprises a second scFv domain.

2 . The trispecific antibody of claim 1 , wherein the first monomer comprises the second scFv domain.

3 . The trispecific antibody of claim 1 , wherein the second monomer comprises the second scFv domain.

4 . A nucleic acid composition comprising:

a) a first nucleic acid encoding the first monomer of claim 1 ;

b) a second nucleic acid encoding the second monomer of claim 1 ; and

c) a third nucleic acid encoding the third monomer of claim 1 .

5 . An expression vector composition comprising:

a) a first expression vector comprising the first nucleic acid of claim 4 ;

b) a second expression vector comprising the second nucleic acid of claim 4 ; and

c) a third expression vector comprising the third nucleic acid of claim 4 .

6 . A host cell comprising the expression vector composition of claim 5 .

7 . A method of making a trispecific antibody comprising culturing the host cell of claim 6 under conditions wherein the trispecific antibody is expressed and recovering the trispecific antibody.