Analogs of pridopidine, their preparation and use
This invention provides an isolated compound having the structure: or a salt thereof, processes for making the same and to compositions comprising pridopidine with these compounds.
1. A pharmaceutical composition comprising pridopidine or salt thereof and compound (1) or salt thereof
and one or more excipients.
2. A pharmaceutical composition comprising pridopidine salt and compound (1) or salt thereof
and one or more excipients.
3. A pharmaceutical composition comprising pridopidine or salt thereof and combination of compound (1) or salt thereof and compound (4) or salt thereof
4. A pharmaceutical composition comprising pridopidine or salt thereof and at least one of compounds 1-8 or salts thereof;
5. The composition of claim 1 , wherein the composition comprises pridopidine salt, wherein the salt is hydrochloride, hydrobromide, nitrate, perchlorate, phosphate, sulphate, formate, acetate; aconate, ascorbate, benzenesulphonate, benzoate cinnamate, citrate, embonate, enantate, fumarate, glutamate, glycolate, lactate, maleate, malonate, mandelate, methane-sulphonate, naphthalene-2-sulphonate, phthalate, salicylate, sorbate, stearate, succinate, tartrate or toluene-p-sulphonate salt.
6. The composition of claim 1 , wherein the composition comprises pridopidine salt, wherein the salt is hydrochloride salt.
7. The composition of claim 3 , wherein the composition comprises pridopidine salt, wherein the salt is hydrochloride, hydrobromide, nitrate, perchlorate, phosphate, sulphate, formate, acetate, aconate, ascorbate, benzenesulphonate, benzoate, cinnamate, citrate, embonate, enantate, fumarate, glutamate, glycolate, lactate, maleate, malonate, mandelate, methane-sulphonate, naphthalene-2-sulphonate, phthalate, salicylate, sorbate, stearate, succinate, tartrate or toluene-p-sulphonate salt.
8. The composition of claim 3 , wherein the composition comprises pridopidine salt, wherein the salt is hydrochloride salt.
9. The composition of claim 1 , in the form of a capsule, a tablet, a pill, a powder, a granule, a liquid solution or a liquid suspension.
10. The composition of claim 3 , in the form of a capsule, a tablet, a pill, a powder, a granule, a liquid solution or a liquid suspension.
11. The composition of claim 1 , in an oral dosage unit form.
12. The composition of claim 3 , in an oral dosage unit form.
13. The composition of claim 11 , wherein the oral dosage unit form comprises between 22.5-315 mg pridopidine.
14. The composition of claim 12 , wherein the oral dosage unit form comprises between 22.5-315 mg pridopidine.
15. The composition of claim 13 , wherein the oral dosage unit form comprises between 45-250 mg pridopidine.
16. The composition of claim 14 , wherein the oral dosage unit form comprises between 45-250 mg pridopidine.
17. The composition of claim 15 , wherein the oral dosage unit form comprises between 45-135 mg pridopidine.
18. The composition of claim 16 , wherein the oral dosage unit form comprises between 45-135 mg pridopidine.
19. The composition of claim 13 , wherein the oral dosage unit form comprises between 90-315 mg pridopidine.
20. The composition of claim 14 , wherein the oral dosage unit form comprises between 90-315 mg pridopidine.
21. The composition of claim 13 , wherein the oral dosage unit form comprises about 22.5 mg pridopidine, about 45 mg pridopidine, about 67.5 mg pridopidine, about 90 mg pridopidine, about 100 mg pridopidine, about 112.5 mg pridopidine, about 125 mg pridopidine, about 135 mg pridopidine, about 150 mg pridopidine, about 180 mg pridopidine, about 200 mg pridopidine, about 250 mg pridopidine, or about 315 mg pridopidine.
22. The composition of claim 14 , wherein the oral dosage unit form comprises about 22.5 mg pridopidine, about 45 mg pridopidine, about 67.5 mg pridopidine, about 90 mg pridopidine, about 100 mg pridopidine, about 112.5 mg pridopidine, about 125 mg pridopidine, about 135 mg pridopidine, about 150 mg pridopidine, about 180 mg pridopidine, about 200 mg pridopidine, about 250 mg pridopidine, or about 315 mg pridopidine.
23. A method of treating Huntington disease in a subject, comprising administering a pharmaceutical composition of claim 1 .
24. A method of treating Huntington disease in a subject, comprising administering a pharmaceutical composition of claim 3 .
25. The method of claim 23 , wherein the composition is administered once daily or more than once daily.
26. The method of claim 24 , wherein the composition is administered once daily or more than once daily.